Apoptosis

1. Front Matter

   Pages i-x

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2. Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans

   • H. Robert Horvitz

   Pages 1-13

3. Apoptosis in Inherited Retinal Degenerations

   • David S. Papermaster, Izhak Nir

   Pages 15-29

4. Wild Type p53 Activity Contributes to Dependence on Hematopoietic Survival Factors

   • Eyal Gottlieb, Rebecca Haffner, Elisheva Yonish-Rouach, Thomas von Ruden, Erwin Wagner, Moshe Oren

   Pages 31-45

5. Regulation of Apoptosis by the Transforming Gene Products of Adenovirus

   • Eileen White, Lakshmi Rao, Shiun-Kwei Chiou, Ching-Chun Tseng, Peter Sabbatini, Michelle Gonzalez et al.

   Pages 47-62

6. C-MYC: Oncogene and Tumour Suppressor Gene

   • Gerard Evan, Trevor Littlewood, David Hancock, Martin Bennett, Elizabeth Harrington, Abdallah Fanidi

   Pages 63-84

7. Regulation of Apoptosis in Interleukin-3-Dependent Myeloid Progenitor Cells

   • John L. Cleveland, David S. Askew, Concha Bello-Fernandez, Graham Packham

   Pages 85-96

8. Ion Signalling in Apoptosis

   • Pierluigi Nicotera, Boris Zhivotovsky, Giorgio Bellomo, Sten Orrenius

   Pages 97-115

9. Molecular Controls of Cell Cycle Progression Following DNA Damage: Roles of P53 and Ataxia-Telangiectasia Gene Products

   • Michael B. Kastan

   Pages 117-135

10. Proliferation Independent Activation of Programmed Cell Death as a Novel Therapy for Prostate Cancer

    • Yuzo Furuya, Richard S. Berges, Per Lundmo, John T. Isaacs

    Pages 137-155

11. The BCL-2 Gene: A Regulator of Programmed Cell Death

    • David M. Hockenbery

    Pages 157-177

12. Nuclear Receptors and Thymocyte Apoptosis: Shaping the Immune Repertoire

    • Melanie S. Vacchio, Yili Yang, Jonathan D. Ashwell

    Pages 179-200

13. Regulation of Cell Growth by Transcription Factors, IRF-1 and IRF-2

    • Tadatsugu Taniguchi, Hisashi Harada, Motoo Kitagawa, Nobuyuki Tanaka, Nobumasa Watanabe, Tohru Kimura

    Pages 201-212

14. MYC, FAS, Apoptosis, and Immune Tolerance

    • Douglas R. Green, Yufang Shi, Jaqueline Glynn, Artin Mahboubi, Rona J. Mogil

    Pages 213-222

15. Induction of Apoptosis by Cell-Cycle Phase Specific Drugs

    • Steven W. Sherwood, Robert T. Schimke

    Pages 223-236

16. Lymphocyte Activation Induced Apoptosis by the APO-1 Cell Surface Receptor

    • Peter H. Krammer

    Pages 237-248

17. Endonucleases Associated with Apoptosis

    • Alan Eastman, Michael A. Barry, Catherine Demarcq, Jinfang Li, Jason E. Reynolds

    Pages 249-264

18. Back Matter

    Pages 265-272

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The fifth Annual Pezcoller Symposium entitled, Apoptosis, was held in Trento, Italy, June 9-1I, 1993 and was focused on the specific phenomena leading to Programmed Cell Death (PCD) or Apoptosis, and the mechanisms involved. With presentations at the cutting edge of progress and stimulating discussions, this Symposium addressed the genetics and molecular mechanisms determining PCD and the role of this suicidal process in cancer and the immune system. The functions of pS3, c myc and bel 2 in affecting apoptosis in different cell types and the role of ions and intracellular pH changes and that of intranuelear endonueleases are given particular emphasis as are the effects of anticancer agents, hormone imbalances and growth factors. The role of pS3, a tumor suppressor gene, in inducing PCD is discussed in detail as pertinent to hematological and non-hernatological tumors. The requirement of pS3 for the induction ofapoptosis by ionizing radiation or adenovirus oncoproteins is outlined. Decision points during the cell cyele affecting the cascade ofevents leading to PCD are discussed as is their role as "switches" under the control of c-myc and bel-2 proteins or the influence of cyele specific drugs. The concurrent requirement of multiple signals in determining apoptosis is emphasized. The examples of the role of PCD in the regulation of hematopoiesis, and in the generation of antigen-specific immune repertoire are illustrated.

• Antigen
• DNA
• apoptosis
• cancer
• cell
• cell death
• cell growth
• gene
• genetics
• growth
• molecular mechanisms
• programmed cell death
• proteins
• regulation
• transcription

• Roswell Park Cancer Institute, Buffalo, USA

  Enrico Mihich

• Stanford University, Stanford, USA

  Robert T. Schimke

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