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Advances in Mercury Toxicology

  • Book
  • © 1991

Overview

Editors:
  1. Tsuguyoshi Suzuki

    1. University of Tokyo, Tokyo, Japan

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  2. Nobumasa Imura

    1. Kitasoto University, Tokyo, Japan

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  3. Thomas W. Clarkson

    1. University of Rochester School of Medicine, Rochester, USA

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Part of the book series: Rochester Series on Environmental Toxicity (RSET)

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. Overview

    1. Overview

      • Tsuguyoshi Suzuki, Nobumasa Imura, Thomas W. Clarkson
      Pages 1-32

  3. Fate in the Environment

    1. Increased Methylmercury Contamination in Fish in Newly Formed Freshwater Reservoirs

      • R. E. Hecky, D. J. Ramsey, R. A. Bodaly, N. E. Strange
      Pages 33-52

    2. Speciation of Mercury in the Environment

      • Hirokatsu Akagi, Hajime Nishimura
      Pages 53-76

  4. Disposition in the Body

    1. Individual Difference of Methylmercury Metabolism in Animals and Its Significance in Methylmercury Toxicity

      • Rikuo Doi
      Pages 77-98

    2. Mechanisms of Urinary Excretion of Methylmercury (MM)

      • Paul J. Kostyniak
      Pages 99-109

    3. Role of Glutathione in Mercury Disposition

      • Akira Naganuma, Toshiko Tanaka, Tsutomu Urano, Nobumasa Imura
      Pages 111-120

    4. Mechanism for Renal Handling of Methylmercury

      • Kimiko Hirayama, Akira Yasutake, Tatsumi Adachi
      Pages 121-134

    5. Methods for Decreasing 203Hg Retention in Relation to Age and Route of Exposure

      • B. Kargacin, K. Kostial
      Pages 135-153

    6. Immunohistochemical Localization of Metallothionein in Organs of Rats Treated with either Cadmium, Inorganic or Organic Mercurials

      • Chiharu Tohyama, Abdul Ghaffar, Atsuhiro Nakano, Noriko Nishimura, Hisao Nishimura
      Pages 155-165

  5. Biotransformation

    1. Mercury Vapor Uptake and Oxidoreductases in Erythrocytes

      • Stefan Halbach
      Pages 167-180

    2. Differential Determination of Ionizable and Unionizable (Inert) Forms of Inorganic Mercury in Animal Tissues

      • Hitoshi Takahashi, Katsutoshi Suetomi, Tetsuro Konishi
      Pages 181-189

  6. Molecular Mechanisms of Toxicity

    1. Role of Neuronal Ion Channels in Mercury Intoxication

      • Toshio Narahashi, Osamu Arakawa, Masanobu Nakahiro
      Pages 191-207

    2. Role of Oxidative Injury in the Pathogenesis of Methylmercury Neurotoxicity

      • M. Anthony Verity, Ted Sarafian
      Pages 209-222

    3. Alterations in Gene Expression Due to Methylmercury in Central and Peripheral Nervous Tissues of the Rat

      • Saburo Omata, Yasuo Terui, Hidetaka Kasama, Tohru Ichimura, Tsuneyoshi Horigome, Hiroshi Sugano
      Pages 223-240

    4. Microtubules: a Susceptible Target of Methylmercury Cytotoxicity

      • Kyoko Miura, Nobumasa Imura
      Pages 241-253

    5. DNA Damage by Mercury Compounds: An Overview

      • Max Costa, Nelwyn T. Christie, Orazio Cantoni, Judith T. Zelikoff, Xin Wei Wang, Toby G. Rossman
      Pages 255-273

  7. Selenium as a Modifying Factor of Mercury Toxicity

    1. Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds

      • Nobumasa Imura, Akira Naganuma
      Pages 275-288

    2. Overview on the Protection Given by Selenium Against Mercurials

      • Laszlo Magos
      Pages 289-298

  8. Toxic Effects of Mercury

    1. Effect of Mercuric Chloride on Angiotensin II-Induced Ca++ Transient in the Proximal Tubule of Rats

      • Hitoshi Endou, Kyu Yong Jung
      Pages 299-314
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Keywords

About this book

This book is based on an international meeting organized by the University of Tokyo and the University of Rochester, and is published as one belonging to the series of Rochester International Conferences in Environmental Toxicity. The meeting on "Advances in Mercury Toxicology" was held at the University of Tokyo on August 1 to 3, 1990. The invited papers are published in this book along with an "Overview" chapter that was written by the editors at a meeting held at the University of Rochester on August 1 to 2, 1991. The purpose of the meeting was to assemble leading scientists to discuss their most recent findings on the toxicology of mercury. The time was opportune. Considerable progress has been made on the environmental fate and toxicology of mercury. Recent findings have given new insight into the global model for mercury. Transport in the atmosphere extends great distances resulting in pollution of lakes and rivers far distant from the source of mercury release. The process of methylation leads to accumulation of methylmercury in fish and thus in the human diet. New evidence indicates that acid rain and the impoundment of water for hydroelectric purposes affects the methylation and bioaccumulation processes resulting in higher levels of methylmercury in fish.

Editors and Affiliations

  • University of Tokyo, Tokyo, Japan

    Tsuguyoshi Suzuki

  • Kitasoto University, Tokyo, Japan

    Nobumasa Imura

  • University of Rochester School of Medicine, Rochester, USA

    Thomas W. Clarkson

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