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The Superfamily of ras-Related Genes

  • Book
  • © 1991

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Editors:
  1. Demetrios A. Spandidos

    1. National Hellenic Research Foundation, Athens, Greece

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Part of the book series: NATO Science Series A: (NSSA, volume 220)

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Table of contents (36 chapters)

  1. Front Matter

    Pages i-x
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  2. Time-Resolved Biochemical Studies of ras Proteins by Fluorescence Measurements on Tryptophan Mutants

    • Bruno Antonny, Michel Roux, Marc Chabre, Pierre Chardin
    Pages 1-13

  3. Prenylation of ras and ras-Related Proteins

    • J. F. Hancock, K. Cadwallader, A. I. Magee, C. Newman, T. Giannakouros, E. Fawell et al.
    Pages 15-22

  4. The YPT Gene Family of Schizosaccharomyces Pombe

    • John Armstrong, Erica Fawell, Sally Hook, Alison Pidoux, Mark Craighead
    Pages 23-29

  5. Phosphorylation of rap Proteins by the cAMP-Dependent Protein Kinase

    • Isabelle Lerosey, Véronique Pizon, Armand Tavitian, Jean de Gunzburg
    Pages 31-39

  6. Regulation of the ras Pathway in the Fission Yeast Schizosaccharomyces Pombe

    • David A. Hughes, Yoshiyuki Imai, Masayuki Yamamoto
    Pages 41-47

  7. Characterization of Normal and Mutant Human Kirsten-ras(4B) p21 and of the Catalytic Domain of GAP

    • Peter N. Lowe, Susan Rhodes, Susan Bradley, Richard H. Skinner
    Pages 49-55

  8. The Signal Transduction Pathway Upstream of CDC25 — ras — Adenylate Cyclase in the Yeast Saccharomyces Cerevisiae and its Relationship to Nutrient Control of Cell Cycle Progression

    • Johan M. Thevelein, Linda Van Aelst, Peter Durnez, Stefan Hohmann
    Pages 57-66

  9. Differential P21 Expression and Point Mutations of ras Gene Family in Human Carcinoma Tissues

    • Yuji Mizukami, Akitaka Nonomura, Fujitsugu Matsubara, Masakuni Noguchi, Shinobu Nakamura
    Pages 67-79

  10. Rearrangement of the Human mel Gene, the rab 8 Homologue, in Human Malignant Melanomas

    • Rose Ann Padua, David Hughes, Elaine Nimmo, Peter Schrier, Keith Johnson
    Pages 81-88

  11. ras Mutations in Preleukaemia, in Patients Following Cytotoxic Therapy and in Normal Subjects

    • G. Carter, D. Hughes, N. Warren, A. Jacobs, J. Whittaker, E. Thomson et al.
    Pages 89-94

  12. Characterization of the Human N-ras Promoter Region

    • J. T. Thorn, A. V. Todd, D. Warrilow, F. Watt, P. L. Molloy, H. J. Iland
    Pages 95-104

  13. ras and rap1 GTPases Mutated at Position 64

    • M. S. A. Nur-E-Kamal, H. Maruta
    Pages 105-110

  14. Progressive Factors in Oncogene Transfected Rodent Embryo Fibroblasts

    • Heather Marshall, Przemyslaw Popowicz, Georg Engel, Catharina Svensson, Göran Akusjärvi, Stig Linder
    Pages 111-119

  15. The YPT-Branch of the ras Superfamily of GTP-Binding Proteins in Yeast: Functional Importance of the Putative Effector Region

    • D. Gallwitz, J. Becker, M. Benli, L. Hengst, C. Mosrin-Huaman, M. Mundt et al.
    Pages 121-128

  16. The v-Ki-ras Oncogene Up-Regulates Major Histocompatibility Class II Antigen Expression in Early-Passage Fibroblasts

    • R. L. Darley, A. G. Morris
    Pages 129-136

  17. Increases in Phospholipase A2 Activity and in the ADP Ribosylation of G Proteins in K-ras-Transformed Thyroid Cells

    • Daniela Corda, Salvatore Valitutti, Luisa Iacovelli, Maria Di Girolamo
    Pages 137-143

  18. Suppression of the Phenotype of T24 H-ras1 Transformed Cells

    • Demetrios A. Spandidos
    Pages 145-151

  19. Search for Correlations between K-ras Oncogene Activation and Pathology, in Sporadic and Familial Colonic Adenomas

    • J. C. Chomel, S. Grandjouan, D. A. Spandidos, M. Tuilliez, C. Bognel, A. Kitzis et al.
    Pages 153-161

  20. Molecular Evolution of the Ha-ras-1 Oncogene: Relationship between DNA Methylation, Frequency of CpG Dinucleotides and Binding to the Sp1 Transacting Factor

    • Roberto Gambari, Stefano Volinia, Giordana Feriotto, Rafaella Barbieri, Roberta Piva, Claudio Nastruzzi
    Pages 163-172
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Keywords

About this book

since the earliest results on the linkage between ras activation and cell transformation appeared a vast amount of additional information has been generated which emphasizes the importance of ras-related genes in membrane trafficking, cell proliferation, differentiation and cancer. These advances led to the development of new strategies for the diagnosis, prognosis and prevention of cancer. Ras-related genes appear to be central to the mechanism of transformation by other oncogenes and therefore constitute a focal point upon which attempts to intervene in the process of carcinogenesis will be concentrated. The present volume contains the contributions to the NATO Advanced Research Workshop on the "The Superfamily of ras-Related Genes" held in Agia Pelagia, Heraklion, Crete, Greece, May 1991. At this meeting the leading researchers in this field carne together to discuss the most recent progress in analysis of biological function of the ras-related genes. As an organizer I feel that the Workshop was a success, and would like to thank all the participants and the contributors to this volume. I thank the NATO Scientific Affairs Division, Brussels, the Greek Ministry of Industry, Energy and Technology, the International Center for Cancer Research, the National Hellenic Research Foundation and the Medical School, University of Crete for sponsoring the Meeting.

Editors and Affiliations

  • National Hellenic Research Foundation, Athens, Greece

    Demetrios A. Spandidos

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