Skip to main content
SpringerLink
Log in

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis

  • Book
  • © 1991

Overview

Editors:
  1. David Z. D’Argenio

    1. University of Southern California, Los Angeles, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  3. Pharmacodynamics: Measurements and Models

    1. Front Matter

      Pages 53-53
      Download chapter PDF

    2. Physiological Alternatives to the Effect Compartment Model

      • Nicholas H. G. Holford
      Pages 55-59

    3. Pharmacokinetics/Dynamics of Corticosteroids

      • William J. Jusko
      Pages 61-68

    4. Variability in Human Cardiovascular Pharmacodynamics

      • Darrell R. Abernethy
      Pages 69-77

    5. Pharmacodynamic Modeling of Thiopental Depth of Anesthesia

      • Donald R. Stanski
      Pages 79-85

  5. Pharmacotherapeutics: Measurement, Control and Delivery

    1. Front Matter

      Pages 153-153
      Download chapter PDF

    2. Development of a Fiber Optic Sensor for Detection of General Anesthetics and Other Small Organic Molecules

      • Sabina Merlo, Paul Yager, Lloyd W. Burgess
      Pages 155-169

    3. A Bayesian Kinetic Control Strategy for Cyclosporin in Renal Transplantation

      • Brian Whiting, Alison A. Niven, Andrew W. Kelman, Alison H. Thomson, Janet Anderson, Angela Munday et al.
      Pages 171-176
Back to top

Keywords

About this book

This volume records the proceedings of the Workshop on Advanced Meth­ ods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics and biomed­ ical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. It has been my experience that in many areas of biomedical research, when a meeting of this type is held, the general attitude of those experimentalists willing to attend is one of extreme skepticism: as a group they feel that mathematical modeling has little to offer them in furthering their understanding of the particular biological processes they are studying. This is certainly not the prevailing view when the topic is pharmacokinetics and drug response. Quite the contrary, the use of mathemati­ cal modeling and associated data analysis and computational methods has been a central feature of pharmacokinetics almost from its beginnings. In fact, the field has borrowed techniques of modeling from other disciplines including applied math­ ematics, statistics and engineering, in an effort to better describe and understand the processes of drug disposition and drug response.

Editors and Affiliations

  • University of Southern California, Los Angeles, USA

    David Z. D’Argenio

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation