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Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis

Editors: Briano, Marcos (Ed.)

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About this book

This volume records the proceedings of the Workshop on Advanced Meth­ ods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics and biomed­ ical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. It has been my experience that in many areas of biomedical research, when a meeting of this type is held, the general attitude of those experimentalists willing to attend is one of extreme skepticism: as a group they feel that mathematical modeling has little to offer them in furthering their understanding of the particular biological processes they are studying. This is certainly not the prevailing view when the topic is pharmacokinetics and drug response. Quite the contrary, the use of mathemati­ cal modeling and associated data analysis and computational methods has been a central feature of pharmacokinetics almost from its beginnings. In fact, the field has borrowed techniques of modeling from other disciplines including applied math­ ematics, statistics and engineering, in an effort to better describe and understand the processes of drug disposition and drug response.

Table of contents (17 chapters)

Table of contents (17 chapters)
  • Predicting Oral Drug Absorption in Humans: A Macroscopic Mass Balance Approach for Passive and Carrier-Mediated Compounds

    Pages 3-11

    Oh, Doo-Man (et al.)

  • Pharmacokinetics of Linear Reversible Metabolic Systems

    Pages 13-20

    Cheng, Haiyung (et al.)

  • Pharmacokinetic Models for Anticancer and Antiviral Drugs Following Administration as Novel Drug Delivery Systems

    Pages 21-36

    Gallo, James M.

  • The Significance of Marked “Universal” Dependence of Drug Concentration on Blood Sampling Site in Pharmacokinetics and Pharmacodynamics

    Pages 37-51

    Chiou, Win L.

  • Physiological Alternatives to the Effect Compartment Model

    Pages 55-59

    Holford, Nicholas H. G.

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-1-4757-9021-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-0-306-44028-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-1-4757-9023-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
Editors
  • Marcos Briano
Copyright
1991
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-9021-4
DOI
10.1007/978-1-4757-9021-4
Hardcover ISBN
978-0-306-44028-1
Softcover ISBN
978-1-4757-9023-8
Edition Number
1
Number of Pages
VIII, 212
Topics