Advances in Experimental Medicine and Biology

Sensory Nerves and Neuropeptides in Gastroenterology

From Basic Science to Clinical Perspectives

Editors: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (Eds.)

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About this book

In the past 15 years much evidence has accumulated which indicates the paramount importance of sensory nerves in reg­ ulating functions of the gastrointestinal tract. In parallel, the attention of researchers in this field has been increas­ ingly attracted to the role played by neuropeptides in the normal and diseased gut. Basic research on the peculiar properties of capsaicin, the pungent ingredient from plants of the genus Capsicum, has allowed the gap between these two areas of research to be bridged. Sincethen, the study of gut afferents and neuropeptides has become more and more interconnected and recognized as a major avenue to understand­ ing the pathophysiology of various human diseases. It is widely recognized that a certain subset of primary afferents synthesize, store and release neuropeptides (such as tachykin­ nins and calcitonin gene-related peptide) from their central and peripheral endings, the latter being widely distributed in the alimentary canal and related organs (liver, pancreas). The First International Meeting on Sensory Nerves and Neuropeptides in Gastroenterology, held in Florence from December 4-5, 1989, sponsored and organized by Fondazione Internazionale Menarini, aimed to focus the current status of research in this field. The contributions presented at the meeting and in this book delineate a suggestive scenario in which sensory nerves of the gut, and the multiple messages they carry through the release of neuropeptides, are to be considered as a major target for the development of new drugs potentially useful in a number of diseases of the gastro­ intestinal tract.

Table of contents (27 chapters)

Table of contents (27 chapters)
  • Capsaicin as a Tool for Studying Sensory Neuron Functions

    Holzer, Peter

    Pages 3-16

  • Chemical Coding of Neurons in the Gastrointestinal Tract

    Costa, M. (et al.)

    Pages 17-27

  • Occurrence and Distribution of Substance P- and CGRP-Containing Nerve Fibers in Gastric Mucosa: Species Differences

    Sundler, F. (et al.)

    Pages 29-37

  • Tachykinin and Calcitonin Gene-Related Peptide Immunoreactivities and Mrnas in the Mammalian Enteric Nervous System and Sensory Ganglia

    Sternini, Catia

    Pages 39-51

  • Peptides and their Receptors on Afferent Neurons to the Upper Gastrointestinal Tract

    Dockray, G. J. (et al.)

    Pages 53-62

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4899-0744-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-0-306-43911-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4899-0746-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sensory Nerves and Neuropeptides in Gastroenterology
Book Subtitle
From Basic Science to Clinical Perspectives
Editors
  • Marcello Costa
  • Calgero Surrenti
  • Sergio Gorini
  • Carlo Alberto Maggi
  • Alberto Meli
Series Title
Advances in Experimental Medicine and Biology
Series Volume
298
Copyright
1991
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4899-0744-8
DOI
10.1007/978-1-4899-0744-8
Hardcover ISBN
978-0-306-43911-7
Softcover ISBN
978-1-4899-0746-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XI, 308
Topics