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Basophil and Mast Cell Degranulation and Recovery

  • Book
  • © 1991

Overview

Authors:
  1. Ann M. Dvorak

    1. Beth Israel Hospital and Harvard Medical School, Boston, USA

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Part of the book series: Blood Cell Biochemistry (BLBI, volume 4)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-viii
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  2. Introduction

    • Ann M. Dvorak
    Pages 1-2

  3. Rat Mast Cells

    • Ann M. Dvorak
    Pages 3-25

  4. Biochemical Contents of Granules and Lipid Bodies—Two Distinctive Organelles Found in Basophils and Mast Cells

    • Ann M. Dvorak
    Pages 27-65

  5. Ultrastructural Morphology of Basophils and Mast Cells

    • Ann M. Dvorak
    Pages 67-99

  6. Degranulation of Basophils and Mast Cells

    • Ann M. Dvorak
    Pages 101-275

  7. Recovery of Basophils and Mast Cells from Degranulation

    • Ann M. Dvorak
    Pages 277-367

  8. Concluding Remarks

    • Ann M. Dvorak
    Pages 369-370

  9. Back Matter

    Pages 371-415
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Keywords

About this book

Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell­ mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.

Authors and Affiliations

  • Beth Israel Hospital and Harvard Medical School, Boston, USA

    Ann M. Dvorak

Bibliographic Information

  • Book Title: Basophil and Mast Cell Degranulation and Recovery

  • Authors: Ann M. Dvorak

  • Series Title: Blood Cell Biochemistry

  • DOI: https://doi.org/10.1007/978-1-4757-9525-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1991

  • Hardcover ISBN: 978-0-306-43752-6Published: 31 August 1991

  • Softcover ISBN: 978-1-4757-9527-1Published: 26 April 2013

  • eBook ISBN: 978-1-4757-9525-7Published: 29 June 2013

  • Series ISSN: 1078-0491

  • Edition Number: 1

  • Number of Pages: VIII, 415

  • Topics: Oncology, Hematology, Immunology, Biochemistry, general, Human Genetics

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