Biochemistry of the Elements

Biochemistry of Halogenated Organic Compounds

Authors: Kirk, Kenneth L.

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About this book

Biochemistry of Halogenated Organic Compounds has been written as a general reference source for researchers in several related areas, including organic chemists, medicinal chemists, pharmacologists, toxicologists, and medical researchers. The development of halogenated compounds as medicinal agents and pharmacological tools and the fascinating biochemi­ cal processes that have been discovered and studied using these analogues have generated extremely active areas of research and an enormous volume of literature. Thus, halogenated organic compounds pervade every aspect of biochemistry, a fact made apparent by the numerous reviews and monographs available on individual topics-halogenated nucleosides, halogenated carbohydrates, and so forth. Given the quantity of material already written on these topics, some of which material is quite current, it might be asked whether a one-volume review of these subjects is useful, or possible. Having now completed this work, I feel the answer to both questions is an emphatic yes. There are fascinating stories to be related in each area, and, where appropriate, I have attempted to develop these topics . from a historical perspective. For example, the discovery of the anticancer activity of fluorouracil, the unraveling of the several mechanisms of its action, and the development of a host of later generations of anticancer and antiviral agents based on the parent fluoro-, iodo-, bromo-, and trifluoromethylpyrimidines were, and are, contributions of major magnitude to medical science.

Table of contents (8 chapters)

  • Biochemistry of Halogenated Carboxylic Acids

    Kirk, Kenneth L.

    Pages 1-39

  • Biochemistry of Halogenated Aldehydes and Ketones

    Kirk, Kenneth L.

    Pages 41-63

  • Biochemistry of Halogenated Analogues of Steroids, Isoprenyl Derivatives, and Other Terpenoids

    Kirk, Kenneth L.

    Pages 65-103

  • Halogenated Analogues of Products of the Arachidonic Acid Cascade: Prostaglandins, Thromboxanes, and Leukotrienes

    Kirk, Kenneth L.

    Pages 105-126

  • Biochemistry of Halogenated Nucleosides and Nucleotides

    Kirk, Kenneth L.

    Pages 127-192

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-1-4757-4605-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-0-306-43657-4
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $139.99
price for USA in USD
  • ISBN 978-1-4757-4607-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biochemistry of Halogenated Organic Compounds
Authors
Series Title
Biochemistry of the Elements
Series Volume
9A+B
Copyright
1991
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4757-4605-1
DOI
10.1007/978-1-4757-4605-1
Hardcover ISBN
978-0-306-43657-4
Softcover ISBN
978-1-4757-4607-5
Edition Number
1
Number of Pages
XVII, 362
Topics