Nato Science Series A:

Targeting of Drugs

Anatomical and Physiological Considerations

Editors: Gregoriadis, Gregory, Poste, George (Eds.)

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About this book

A major vehicle for the transition of carrier-mediated drug delivery from a theoretical/experimental status to one with practical uses has been the NATO Advanced Studies Institute series "Targeting of Drugs". Three previous ASls of the series[1-3], also held in Cape Sounion, dealt with carriers of natural and synthetic origin, their preparation and drug incorporation as well as a wide range of applications. This book contains the proceedings of the 4th NATO ASI "Targeting of Drugs: Anatomical and Physiological Considerations" held in Cape Sounion, Greece during 20 June - 1 July 1987. Historically, carrier systems have been chosen on the basis of selective affinity for target sites. For instance, monoclonal antibodies bind selectively to antigens on the surface of cells and the same applies to ligands such as certain glycoproteins which bind to cell receptors. Colloidal carriers on the other hand, are "passively" targeted to the reticuloendothelial system. However, effective drug delivery depends not only on demonstration of affinity of the carrier system for its target but also, and perhaps crucially, on the way(s) by which the carrier-drug entity interacts with the interposed biological milieu. The book deals in depth with a number of biological milieus as travelled space for carriers en route to their destination, difficulties arising from unfavorable milieu-carrier interactions and ways to circumvent such difficulties. It also identifies, when possible, situations where proposed uses would or would not be realistic and provides perspectives for future goals.

Reviews

From Book News, Inc.
Proceedings of the conference held June 20-July 1, 1987 in Cape Sounion, Greece. Contributors deal in depth with numerous biological milieus as travelled space for carriers enroute to their destination, difficulties arising from unfavorable milieu-carrier interactions, and ways to circumvent such difficulties. Situations where proposed uses would or would not be realistic are also identified. Liberal use of graphics. Produced from uniform typescript.
Annotation copyright Book News, Inc. Portland, Or.


Table of contents (18 chapters)

  • The Structure of Different Types of Liver Cells in Relation to Uptake and Exchange Processes

    Geerts, Albert (et al.)

    Pages 1-14

  • The Lymphatic System in Drug Targeting: An Overview

    Hall, J. G.

    Pages 15-28

  • The Hepatic Receptor for Asialoglycoproteins: Search for a Function

    Steer, J. Clifford (et al.)

    Pages 29-43

  • The Galactose-Particle Receptor on Liver Macrophages: Biological Function and Implications for Clearance of Particulate Material

    Kolb-Bachofen, Victoria

    Pages 45-51

  • Free Radicals in Health and Disease: Implications for Drug Delivery and Targeting

    Rice-Evans, Catherine

    Pages 53-67

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-1-4684-5574-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA in USD
  • ISBN 978-0-306-43023-7
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4684-5576-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Targeting of Drugs
Book Subtitle
Anatomical and Physiological Considerations
Editors
  • Gregory Gregoriadis
  • George Poste
Series Title
Nato Science Series A:
Series Volume
155
Copyright
1988
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5574-8
DOI
10.1007/978-1-4684-5574-8
Hardcover ISBN
978-0-306-43023-7
Softcover ISBN
978-1-4684-5576-2
Edition Number
1
Number of Pages
222
Topics