Cancer Biology and Therapeutics

1. Front Matter

   Pages i-x

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2. Biochemistry of the Cancer Cell and Selectivity of Drug Action

   1. Front Matter

      Pages 1-1

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   2. Biochemical Strategy of Cancer Cells and the Targeting of Chemotherapy with Tiazofurin, Acivicin, and Dipyridamole

      • George Weber

      Pages 3-21

   3. The Biological Bases for the Design of Anticancer Agents

      • John A. Montgomery

      Pages 23-42

   4. Biochemistry of Methotrexate: Teaching an Old Drug New Tricks

      • F. M. Huennekens, T. H. Duffy, L. E. Pope, G. G. Grundler, J. K. Sato, K. S. Vitols

      Pages 43-61

3. Biological and Clinical Implications of Tumor Cell Heterogeneity and Metastases

   1. Front Matter

      Pages 63-63

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   2. Biological and Clinical Implications of the Stem Cell Concept in Human Malignancy

      • Ronald N. Buick

      Pages 65-77

   3. Membrane Properties of Lewis Lung Tumor Cells with “Low” and “High” Metastatic Capacity: Anti-Metastatic Effect of a Glycosaminoglycan Biosynthesis Blocking Agent 5-Hexyl-2′-Deoxyuridine (HUdR)

      • Károly Lapis, József Timár, Katalin Pál, András Jeney, Ferenc Timár, László Kopper

      Pages 79-94

   4. Implications of Therapy-Induced Genetic/Epigenetic Modulations of Tumor Progression and Tumor Cell Heterogeneity for the Treatment of Cancer

      • Robert S. Kerbel, Robert G. Liteplo, Phil Frost

      Pages 95-104

4. Approaches to the Treatment and Diagnosis of Cancer

   1. Front Matter

      Pages 105-105

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   2. Site-Directed Combination Chemotherapy

      • Joseph G. Cory

      Pages 107-117

   3. Sugar Analogs and 5-Fluorouridine in Combination Chemotherapy

      • Dietrich Keppler, Axel Holstege, Gisbert Weckbecker

      Pages 119-126

   4. New Strategies for the Improvement of Alkylating Antitumor Agents

      • H. Grunicke, W. Doppler, J. Hofmann, H. Lindner, K. Maly, H. Oberhuber et al.

      Pages 127-139

   5. Application of Proton Nuclear Magnetic Resonance to Tumor Biology

      • Paul G. Braunschweiger, Marvin A. Rich

      Pages 141-157

5. Clinical Advances and Problems in the Treatment of Human Tumors

   1. Front Matter

      Pages 159-159

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   2. Relationships of Cell Biology to Therapy in Childhood Leukemia

      • A. Thomas Look, Dorothy L. Williams, Joseph V. Simone

      Pages 161-171

   3. Clinical Cancer Treatment and Drug Resistance: The Interface of the Clinic and the Laboratory

      • Eddie Reed, Bruce A. Chabner

      Pages 173-179

6. Induction, Prevention, and Modulation of Cancer

   1. Front Matter

      Pages 181-181

      PDF

   2. Nitrosamines and Human Cancer: Some Implications of Basic Research

      • Peter N. Magee

      Pages 183-195

   3. Molecular Mechanisms in Protection Against Carcinogenesis

      • Paul Talalay, Mary J. De Long, Hans J. Prochaska

      Pages 197-216

In anticipation of the opening of the H. Lee Moffitt Cancer Center and Research lnstitut~ on the campus of the University of South Florida, an international symposium, "The First Annual H. Lee Moffitt Symposium on Cancer Biology and Therapeutics" was held in Tampa, Florida on January 20-22, 1986. In this first symposium we decided to present a broad-based series of topics dealing with the major issues in the field of cancer. These topics ranged from the biochemistry of the cancer cell to the design of antineoplastic agents, through tumor cell heterogeneity, treatment of ltuman neoplasms to immunological aspects of cancer biology and tr~atment. The speakers chosen represented individuals of international acclaim who are very active in the area of cancer research and treatment. The symposium brought together scien­ tists/physicians from six nations including Austria, Canada, France, Hungary, West Germany, and of course, the United States. The congeniality of the participants promoted the friendly exchange of knowledge which, it is hoped, will greatly hasten the time when successful management of human cancer will become routine. Future symposia in this series will be highly focused and will deal with a single facet of this vast field of cancer research and treatment. Joseph G. Cory, Editor Andor Szentivanyi, Editor University of South Florida, 1986 V ACKNOWLEDGMENTS This volume presents the Proceedings of the H. Lee Moffitt International Syn~osium on Cancer Biology and Therapeutics which was held in Tampa, Florida on January 20, 21, and 22, 1986.

• cancer treatment
• carcinogenesis
• cell
• cell biology
• immunology
• leukemia
• lymphocytes
• membrane
• metastasis
• prevention
• stem cell
• tumor
• tumor progression

• University of South Florida, Tampa, USA

  Joseph G. Cory, Andor Szentivanyi

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