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Principles of Endocrine Pharmacology

  • Book
  • © 1986

Overview

Authors:
  1. John A. Thomas

    1. Corporate Research, Travenol Laboratories, Inc., Round Lake, USA
      Department of Pharmacology, Northwestern University School of Medicine, Chicago, USA
      Department of Urology, Northwestern University School of Medicine, Chicago, USA
      Department of Pharmacology and Toxicology, West Virginia School of Medicine, Morgantown, USA
      Department of Pharmacology, University of Illinois School of Medicine, Chicago, USA
      Department of Pharmacology, Rush-Presbyterian School of Medicine, Chicago, USA

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  2. Edward J. Keenan

    1. Hormone Receptor Laboratory, School of Medicine, The Oregon Health Sciences University, Portland, USA
      Department of Surgery, School of Medicine, The Oregon Health Sciences University, Portland, USA
      Department of Pharmacology, School of Medicine, The Oregon Health Sciences University, Portland, USA
      Department of Medicine (Medical Oncology), School of Medicine, The Oregon Health Sciences University, Portland, USA

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Introduction and General Mechanisms of Hormonal Actions

    • John A. Thomas, Edward J. Keenan
    Pages 1-14

  3. Pharmacology of Adenohypophyseal Hormones

    • John A. Thomas, Edward J. Keenan
    Pages 15-42

  4. Posterior Pituitary Hormones, Oxytocics, and Prostaglandins

    • John A. Thomas, Edward J. Keenan
    Pages 43-68

  5. Thyroid and Antithyroidal Drugs

    • John A. Thomas, Edward J. Keenan
    Pages 69-91

  6. Parathyroid Hormone and Calcitonin

    • John A. Thomas, Edward J. Keenan
    Pages 93-109

  7. Androgenic and Anabolic Steroids

    • John A. Thomas, Edward J. Keenan
    Pages 111-133

  8. Estrogens and Antiestrogenic Drugs

    • John A. Thomas, Edward J. Keenan
    Pages 135-165

  9. Progestins and Oral Contraceptives

    • John A. Thomas, Edward J. Keenan
    Pages 167-196

  10. Adrenocorticosteroid Drugs

    • John A. Thomas, Edward J. Keenan
    Pages 197-227

  11. Insulin and Oral Hypoglycemic Agents

    • John A. Thomas, Edward J. Keenan
    Pages 229-256

  12. Effects of Drugs on the Endocrine System

    • John A. Thomas, Edward J. Keenan
    Pages 257-290

  13. Back Matter

    Pages 291-294
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Keywords

About this book

The authors have provided an overview of the relationships between hormones that are physiologic constituents of the body as well as their pharmacologic use in replacement therapies and related endocrine dys­ function. Principles of Endocrine Pharmacology concerns itself with the ther­ apeutic use of hormones, and hormone like substances, or drugs that can act either by suppressing or enhancing the metabolism of certain glands of internal secretion. Other drugs used for nonendocrine ther­ apies can likewise affect the endocrine system. Endocrine pharmacology emerged in the early 1900s with the use of crude pituitary extracts. By the mid-1900s several investigators had isolated and begun to synthesize hormones or hormonelike substances. Recognizing the limited supply of hormones that could be obtained both from animal sources and human autopsy material, the search for so­ called hormone substitutes also began early in the 1900s. Recently, re­ combinant DNA technologies have been used to provide alternative therapeutic sources of human insulin and human growth hormone. Aside from insulin, perhaps no other use of hormonally-active sub­ stance is better exemplified by those drugs which affect fertility. The synthesis of an orally-effective steroid represented one of the first major breakthroughs in the chemical suppression of ovulation. Since the orally­ active 19-norsteroids were introduced in the 1950s, several oral contra­ ceptive steroid preparations have been marketed. Indeed, the advent of oral contraceptives for birth control has led to a renewed interest in endocrine pharmacology.

Authors and Affiliations

  • Corporate Research, Travenol Laboratories, Inc., Round Lake, USA

    John A. Thomas

  • Department of Pharmacology, Northwestern University School of Medicine, Chicago, USA

    John A. Thomas

  • Department of Urology, Northwestern University School of Medicine, Chicago, USA

    John A. Thomas

  • Department of Pharmacology and Toxicology, West Virginia School of Medicine, Morgantown, USA

    John A. Thomas

  • Department of Pharmacology, University of Illinois School of Medicine, Chicago, USA

    John A. Thomas

  • Department of Pharmacology, Rush-Presbyterian School of Medicine, Chicago, USA

    John A. Thomas

  • Hormone Receptor Laboratory, School of Medicine, The Oregon Health Sciences University, Portland, USA

    Edward J. Keenan

  • Department of Surgery, School of Medicine, The Oregon Health Sciences University, Portland, USA

    Edward J. Keenan

  • Department of Pharmacology, School of Medicine, The Oregon Health Sciences University, Portland, USA

    Edward J. Keenan

  • Department of Medicine (Medical Oncology), School of Medicine, The Oregon Health Sciences University, Portland, USA

    Edward J. Keenan

Bibliographic Information

  • Book Title: Principles of Endocrine Pharmacology

  • Authors: John A. Thomas, Edward J. Keenan

  • DOI: https://doi.org/10.1007/978-1-4684-5036-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Publishing Corporation 1986

  • Softcover ISBN: 978-0-306-42143-3Published: 30 June 1986

  • eBook ISBN: 978-1-4684-5036-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 310

  • Topics: Diabetes, Internal Medicine, General Practice / Family Medicine, Pharmacology/Toxicology

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