Chronic Renal Disease

1. Front Matter

   Pages i-xvi

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2. Studies of Pathogenesis of Renal Disease

   1. Front Matter

      Pages 1-1

      PDF

   2. Research Trends in Glomerular Diseases

      1. A Personal Perspective on the State of the Art in Research in Glomerulonephritis

         • Richard J. Glassock

         Pages 5-7

      2. Biosynthesis and Immunochemical Localization of Glomerular Components

         • Gary E. Striker, Federico M. Farin, Paul D. Killen, Jeffrey F. Bonadio

         Pages 9-14

      3. The Role of Fixed (Native) and Planted Antigens in Glomerular Disease

         • Curtis B. Wilson

         Pages 15-28

      4. Deposition of Circulating Immune Complexes in Glomeruli

         • Mart Mannik

         Pages 29-38

   3. Cystic Diseases of the Kidney

      1. Renal Cystic Disease as the Target of Research

         • Kenneth D. Gardner Jr.

         Pages 41-46

      2. Morphology of Human Renal Cystic Disease

         • Jay Bernstein

         Pages 47-54

      3. Morphology of Polycystic Kidney Disease in Man and Experimental Models

         • Andrew P. Evan, Kenneth D. Gardner Jr.

         Pages 55-68

      4. Ordered and Disordered Growth of Renal Cells

         • F. Gary Toback

         Pages 69-78

      5. Movements of Salts and Water into Cysts in Polycystic Kidney Disease

         • Jared Grantham

         Pages 79-87

      6. Movement of Organic Molecules into Cysts

         • William M. Bennett, Curtis G. Wickre, Richard S. Muther

         Pages 89-93

      7. Kinetics of Cyst Development in Cystic Renal Disease

         • Larry W. Welling, Dan J. Welling

         Pages 95-103

      8. Early Polycystic Kidney Disease

         • Joseph H. Holmes, Patricia Gabow

         Pages 105-112

3. Recent Advances on Some Complications of Chronic Renal Failure

   1. Front Matter

      Pages 113-113

      PDF

   2. Renal Osteodystrophy, Vitamin D Analogues, Parathormone

      1. An Overview of Recent Advances in Mineral Metabolism

         • Saulo Klahr, Eduardo Slatopolsky, Kevin Martin

         Pages 117-125

      2. The Pathology of the Uremic Bone Lesion

         • Steven L. Teitelbaum

         Pages 127-138

      3. Vitamin D Metabolism in Chronic Renal Disease

         • Jacob Lemann Jr., Richard W. Gray, Nancy D. Adams

         Pages 139-153

      4. Metabolism of Parathyroid Hormone and Interpretation of Radioimmunoassays for PTH

         • Eduardo Slatopolsky, Kevin Martin, Keith Hruska, Saulo Klahr

         Pages 155-163

      5. Collagen Metabolism in Uremia

         • Stephen M. Krane

         Pages 165-172

Chronic renal disease has received increasing attention and concern since the passage in 1972 of PL 92-603, which provided coverage for end-stage renal disease (ESRD) treatment by the federal government. The human and economic costs of the ESRD program serve to emphasize the need to prevent or to arrest those diseases resulting in chronic renal failure, since none of the available treatments is without complications and/or side effects. The ESRD program, the only federal one that provides coverage for a catastrophic illness for almost the entire population (those qualifying under Social Security), cost almost $2 billion in 1983. The escalating costs of the ESRD program are attributed to the increasing number of patients requiring treatment and have focused concerns of the United States Government, both Congress and the administration, on ESRD. The National Institutes of Health (NIH), especially the Kidney, Urology, and Hematology Division of the National Institutes of Arthritis, Diabetes, and Digestive and Kidney Diseases (NIADDK), supports a sizable research program that bears on chronic renal disease and in association with this has sponsored many conferences and workshops on research on and causes and complications of chronic renal failure. This book is an outgrowth of the issues addressed by participants at a number of NIH conferences held in the 1980s.

• diseases
• glomerulonephritis
• growth
• kidney
• nutrition
• pathology
• physiology
• therapy
• transplantation
• urology

• National Institutes of Health, Bethesda, USA

  Nancy Boucot Cummings

• Washington University School of Medicine, St. Louis, USA

  Saulo Klahr

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