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Environmental Science Research

Individual Susceptibility to Genotoxic Agents in the Human Population

Authors: De Serres, Frederick J., Pero, Ronald W., Sheridan, William

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About this book

As a result of the industrial revolution, man's technological achievements have been truly great, increasing the quality of life to almost unimagined proportions; but all this progress has not been accomplished without equally un imagined health risks. Sufficiently diagnostic short-term assay procedures have been developed in recent years for us to determine that there are mutagenic agents among thou­ sands of chemicals to which the human population is exposed today. These chemicals were not significantly present prior to the indus­ trial revolution. As of today, there are no procedures available which have been adequately demonstrated to assess individual sus­ ceptibility to genotoxic exposures, and as a result we have had to rely on extrapolating toxicological data from animal model systems. The question is can we afford to allow such an increased environ­ mental selection pressure via mutagenic exposures to occur without expecting adverse long-term effects on our health. It is apparent from this line of reasoning that what is lacking and immediately needed are test procedures that can be applied to humans to assess genotoxic exposure as well as individual susceptibility to it. There have already been two conferences which have focused at­ tention on this research area. "Guidelines for studies of human populations exposed to mutagenic and reproductive hazards" (A. D. Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B. A. Bridges, B. E. Butterworth, and I. B.

Table of contents (30 chapters)

  • Investigation of Genetic Hazards: Guidance from Occupational and Environmental Studies

    Selikoff, Irving J.

    Pages 1-20

  • Epidemiology and Population Monitoring in Genetic Risk Assessment

    Hook, Ernest B.

    Pages 21-31

  • An Overview of Approaches for Genetic Monitoring of Humans

    Sutton, H. Eldon

    Pages 33-52

  • Evaluation of Genotoxic Effects in Human Populations

    Waters, M. D. (et al.)

    Pages 53-87

  • On the Possible Significance of TCDD Receptor Based Assays in Attempts to Estimate Environmental Health Hazards

    Gustafsson, Jan Åke (et al.)

    Pages 89-108

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4613-2765-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA in USD
  • ISBN 978-0-306-41679-8
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4612-9709-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Individual Susceptibility to Genotoxic Agents in the Human Population
Authors
Series Title
Environmental Science Research
Series Volume
30
Copyright
1984
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4613-2765-3
DOI
10.1007/978-1-4613-2765-3
Hardcover ISBN
978-0-306-41679-8
Softcover ISBN
978-1-4612-9709-3
Edition Number
1
Number of Pages
518
Topics