Interrelations between Essential Metal Ions and Human Diseases

1. Front Matter

   Pages i-xxxvii

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2. Metal Ions and Infectious Diseases. An Overview from the Clinic

   • Peggy L. Carver

   Pages 1-28

3. Sodium and Potassium in Health and Disease

   • Hana R. Pohl, John S. Wheeler, H. Edward Murray

   Pages 29-47

4. Magnesium in Health and Disease

   • Andrea M. P. Romani

   Pages 49-79

5. Calcium in Health and Disease

   • Marisa Brini, Denis Ottolini, Tito Calì, Ernesto Carafoli

   Pages 81-137

6. Vanadium. Its Role for Humans

   • Dieter Rehder

   Pages 139-169

7. Chromium: Is It Essential, Pharmacologically Relevant, or Toxic?

   • John B. Vincent

   Pages 171-198

8. Manganese in Health and Disease

   • Daiana Silva Avila, Robson Luiz Puntel, Michael Aschner

   Pages 199-227

9. Iron: Effect of Overload and Deficiency

   • Robert C. Hider, Xiaole Kong

   Pages 229-294

10. Cobalt: Its Role in Health and Disease

    • Kazuhiro Yamada

    Pages 295-320

11. Nickel and Human Health

    • Barbara Zambelli, Stefano Ciurli

    Pages 321-357

12. Copper: Effects of Deficiency and Overload

    • Ivo Scheiber, Ralf Dringen, Julian F. B. Mercer

    Pages 359-387

13. Zinc and Human Disease

    • Wolfgang Maret

    Pages 389-414

14. Molybdenum in Human Health and Disease

    • Guenter Schwarz, Abdel A. Belaidi

    Pages 415-450

15. Silicon: The Health Benefits of a Metalloid

    • Keith R. Martin

    Pages 451-473

16. Arsenic. Can This Toxic Metalloid Sustain Life?

    • Dean E. Wilcox

    Pages 475-498

17. Selenium. Role of the Essential Metalloid in Health

    • Suguru Kurokawa, Marla J. Berry

    Pages 499-534

18. Back Matter

    Pages 535-573

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MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, arethoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

• Essential Metals
• Human Diseases
• Metal Deficiency
• Metal Homeostasis
• Metal Overload

From the book reviews:

“This volume, which lies at the natural juncture between chemistry, biology, physiology, biochemistry, pharmacology and medicine, provides the basis for understanding the important roles played by metal ions and the clinical consequences of an imbalance in their homeostasis. I have no doubt that this volume will serve not only as a source of inspiration as well as an important reference point for academics working in this research field, but will also act as an invaluable resource for undergraduate teaching.” (Celine J. Marmion, Transition Metal Chemistry, Vol. 39, 2014)

“The book is a great compilation of high-quality review articles describing how essential metals and metalloids correlate with human diseases. Its interdisciplinary line-up ensures that every reader will learn something new when browsing through the book. Each of its chapters is well suited to serve both as a reference for scientists already familiar with the respective subject andas a starting point for novices. … deserves a place in every scientific library and on the shelf of every bioinorganic chemist.” (Jens Müller, Inorganica Chimica Acta, Vol. 423, 2014)

• Dept. of Chemistry, Inorganic Chemistry, University of Basel, Basel, Switzerland

  Astrid Sigel

• Department of Chemistry, Inorganic Chemistry, University of Basel, Basel, Switzerland

  Helmut Sigel

• Institute of Inorganic Chemistry, University of Zürich, Zürich, Switzerland

  Roland K.O. Sigel

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