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Life Sciences - Biochemistry & Biophysics | Cell Biochemistry and Biophysics - incl. option to publish open access

Cell Biochemistry and Biophysics

Cell Biochemistry and Biophysics

Editor-in-Chief: Lawrence Berliner

ISSN: 1085-9195 (print version)
ISSN: 1559-0283 (electronic version)

Journal no. 12013

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Information for Authors

Your cover letter must include a valid institutional email address for each author. If this is not possible, the cover letter must include a means of verifying each author – such as an ORCID or Scopus ID or a link to their publication record(s).

Please suggest potential reviewers for this submission. Please remember that the reviewers you suggest should be totally independent, and not connected to you or your work in any way.

We strongly recommend that you suggest a mix of reviewers from different countries and different institutions - recommending reviewers only from your home country or your own institution is likely to result in your paper being rejected. In the 'Reason' field, you must also fill in the reviewer's country.

Also please ensure that you provide complete and accurate contact information for your suggested reviewers, including a valid institutional email address, ORCID or Scopus ID, or link to a publication record. Incomplete or incorrect information is also likely to result in your paper being rejected.



Preparation of Manuscripts for Consideration for Publication in CELL BIOCHEMISTRY and BIOPHYSICS
Authors should submit their manuscripts online. Electronic submission substantially reduces the editorial processing and reviewing times and shortens overall publication times. Please directly visit the site: and upload all of your manuscript files following the instructions provided on the screen.


• Cell Biochemistry and Biophysics will consider for publication papers from any field of biochemical, biomedical, biophysical, bioengineering and biomathematics research and any field impinging thereupon.
• The Journal strives to publish only papers of high scientific quality. Therefore, without exception, all manuscripts are peer-reviewed and the Journal requires three reviewers for each manuscript. However, finding qualified/knowledgeable reviewers who are willing to review in a timely manner can be a time-consuming process. Therefore, to expedite this process, we strongly recommend the author(s), as experts in the subject matter of the manuscript, nominate at least six potential reviewers to review the manuscript in a comprehensive and unbiased manner for its suitability for publication in Cell Biochemistry and Biophysics.
• All manuscripts must be written in grammatically correct English. Correct English spelling is required. It is suggested that non-native English speaking authors have their manuscript reviewed by a native English speaker. Failure to do so may result in return of the manuscript for revision before it is peer-reviewed.
• Manuscripts should be submitted to the Cell Biochemistry and Biophysics Editorial Manager website at: http://cbbi.edmgr.com.
• Manuscripts must be submitted in Word Document format. Figures should be submitted in TIF or JPEG format.
• The: (1) Text of the manuscript (which must include the Title Page, Abstract, Body of the Manuscript, Bibliography and Figure Legends), (2) Tables and (3) Figures must be placed in separate files.
• Note that the incorporation of illustrations, data of any conceivable type, quotations, etc. from your published works, as well as those of others, requires written permission from the copyright owner for their use and acknowledgement thereof in the manuscript.
• All figures and tables are to be formatted in a font size that can be read by the unaided eye.
• There is no upper limit on the size of manuscripts.
• Manuscripts must contain a comprehensive bibliography in the format noted below.
• Type manuscript in English.
• Type manuscript double-spaced on with 1- to 1-1/ 2-in. margins.
• Include legends for all Figures and Tables. Legends should be numbered and typed consecutively and serially.


• Number figures consecutively with Arabic numerals.
• Include Figure captions. Callouts, if any, should be capital letters and readily recognizable.
• All illustrations, including chemical structures, must be of professional-quality and in finished form ready for direct reproduction without revision by the publisher. Color art cannot be accepted unless the author(s) can assume the additional costs involved in production. Quotes will be given on request (see below).
• Place each table on a separate page.
• Number consecutively with Arabic numerals in order of mention in the text.
• Provide titles and legends for all tables.


• Cite in-text with italic Arabic numerals in parentheses set on the text line.
• List at the end of the paper in consecutive order.
• Citing papers in press is to be avoided. If the data in such papers are of importance to the work submitted, they should be included in the manuscript. Follow the style indicated below:
Journal reference:
Puskar K, Ta 'asan S, Schwartz R, LeDuc PR (2006) Evaluating spatial constraints in cellular assembly processes using a monte carlo approach. Cell Biochem Biophys. 2006. 45, 195-201.
Chapter in book:
Francis MJ and Monaco AP (2002) The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein, in Handbook of Copper Pharmacology and Toxicology (Massaro, EJ, ed), Humana, Totowa, NJ, pp. 209-226.
Book reference:
Walz, W. (2002) Patch-Clamp Analysis, Humana, Totowa, NJ.
Wilk, SJ, Aboud S, Petrossian L, Goyll M, Tang JM, Eisenberg RS, Saraniti M, Goodnick SM, Thornton TJ. (2006) Ion Channel Conductance Measurements on a Silicon-Based Platform, XDDARPA, AD Number: ADA464359, Source Code: 414890, Defense Technical Information Center (DTIC) Scientific and Technical Information Network (STINET), Technical Reports Collection.
• Include 5-10 index entries/keywords.


• No page charges accrue to publication.


• There is a charge for color illustrations. For pricing information, contact the Publisher at:


• Reprints are available to authors at standard rates.


• Divide research papers into: Abstract, Introduction, Materials and Methods, Results, Discussion and Bibliography followed by the Figures and Tables.
• Abstracts should be limited to 100-200 words, if possible.
• The first paragraph of the Introduction must delineate the hypothesis tested and the conclusion(s) derived from the Results. The purpose of the Discussion is to examine the Results in relation to current knowledge.
• Verification of the identity of cell lines must be included in Materials and Methods section of Research Manuscripts and the methodology employed referenced in the Bibliography.
For example:
Parson et al. (2005) Cancer cell line identification by short tandem repeat profiling: power and limitations. FASEB J. 19(3):434-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Citation&list_uids=15637111
Masters et al. (2001) Short tandem repeat profiling provides an international reference standard for human cell lines. Proc.Natl.Acad.Sci.U.S.A 98(14): 8012-8017
• For newly-purchased cell lines: To circumvent in-house verification of cell line identity and purity, the purchaser should demand certification from the supplier that the lines have been verified to be of the correct lineage and uncontaminated by other cell types or organisms. This information must be included in the Materials and Methods section of the manuscript.
• Lack of verification will require a written justification on the part of authors and its acceptance by the Publication Committee of the Journal's Editorial Advisory Board prior to acceptance of a manuscript for publication. The justification must be included in the Materials and Methods section of the manuscript.


• Reviews must critically and thoroughly review a particular field and are expected to be as current as possible.
• Reviews may contain unpublished data of the author(s). Such data must be noted in the Bibliography/References section of the paper and designated as unpublished data.
• Reviews require an Introduction followed by the body of the manuscript (whose sections are appropriately labeled), Figures and Tables.
• Reviews are expected to contain an exhaustive bibliography comprised of complete references (as noted below) and be as current as possible.
• Divide technical notes/position papers into: Abstract, Introduction, Discussion and Bibliography followed by the Figures and Tables.
• Abstracts should be limited to 200 words, if possible.
• The Introduction must define the problem/position to be examined. The purpose of the Discussion is to thoroughly dissect the problem/position and the potential/real consequence(s) of non-resolution.
• AUTHENTICATION OF CELL LINES is required for TECHNICAL NOTES. Refer to the instructions in the RESEARCH MANUSCRIPTS section (above).


• Hypotheses must be: (i) logical in the light of current knowledge and (ii) present a unique interpretation of current data not previously considered in the literature that, nevertheless, is irrefutably logical. The logic must be clearly stated and supported by current published data (i.e., be an equally logical alternative interpretation of existing, confirmed data). The bottom line is that the authors must convince reviewers that their interpretation is, at least, an equally viable interpretation of the data upon which the current dogma is based.
• Hypotheses require an Introduction followed by the body of the manuscript (whose sections are appropriately labeled).
• Illustrations (including cartoons) should be included for purposes of clarification. Hypotheses are expected to contain an exhaustive bibliography comprised of complete references (as noted above) and be as current as possible.

English Language Editing 

For editors and reviewers to accurately assess the work presented in your manuscript you need to ensure the English language is of sufficient quality to be understood. If you need help with writing in English you should consider:
  • Asking a colleague who is a native English speaker to review your manuscript for clarity.
  • Visiting the English language tutorial which covers the common mistakes when writing in English.
  • Using a professional language editing service where editors will improve the English to ensure that your meaning is clear and identify problems that require your review. Two such services are provided by our affiliates Nature Research Editing Service and American Journal Experts. Springer authors are entitled to a 10% discount on their first submission to either of these services, simply follow the links below.
Please note that the use of a language editing service is not a requirement for publication in this journal and does not imply or guarantee that the article will be selected for peer review or accepted.
If your manuscript is accepted it will be checked by our copyeditors for spelling and formal style before publication.


● 请一位以英语为母语的同事审核您的稿件是否表意清晰。
● 查看一些有关英语写作中常见语言错误的教程。
● 使用专业语言编辑服务,编辑人员会对英语进行润色,以确保您的意思表达清晰,并识别需要您复核的问题。我们的附属机构 Nature Research Editing Service 和合作伙伴 American Journal Experts 即可提供此类服务。


・プロの英文校正サービスを利用する。校正者が原稿の意味を明確にしたり、問題点を指摘し、英語の質を向上させます。Nature Research Editing Service とAmerican Journal Experts の2つは弊社と提携しているサービスです。Springer の著者は、いずれのサービスも初めて利用する際には10%の割引を受けることができます。以下のリンクを参照ください。


영어 원고의 경우, 에디터 및 리뷰어들이 귀하의 원고에 실린 결과물을 정확하게 평가할 수 있도록, 그들이 충분히 이해할 수 있을 만한 수준으로 작성되어야 합니다. 만약 영작문과 관련하여 도움을 받기를 원하신다면 다음의 사항들을 고려하여 주십시오:
• 귀하의 원고의 표현을 명확히 해줄 영어 원어민 동료를 찾아서 리뷰를 의뢰합니다.
• 영어 튜토리얼 페이지에 방문하여 영어로 글을 쓸 때 자주하는 실수들을 확인합니다.
• 리뷰에 대비하여, 원고의 의미를 명확하게 해주고 리뷰에서 요구하는 문제점들을 식별해서 영문 수준을 향상시켜주는 전문 영문 교정 서비스를 이용합니다. Nature Research Editing Service와 American Journal Experts에서 저희와 협약을 통해 서비스를 제공하고 있습니다. Springer 저자들이 본 교정 서비스를 첫 논문 투고를 위해 사용하시는 경우 10%의 할인이 적용되며, 아래의 링크를 통하여 확인이 가능합니다.
영문 교정 서비스는 게재를 위한 요구사항은 아니며, 해당 서비스의 이용이 피어 리뷰에 논문이 선택되거나 게재가 수락되는 것을 의미하거나 보장하지 않습니다.
원고가 수락될 경우, 출판 전 저희측 편집자에 의해 원고의 철자 및 문체를 검수하는 과정을 거치게 됩니다.


• The Journal is interested in publishing Special Issues focused on individual topics of particular interest to its readership. Included in this category are the proceedings of symposia, conferences, etc.
• State-of-the-art research papers presenting unpublished data and topical reviews.

Ethical Responsibilities of Authors 

This journal is committed to upholding the integrity of the scientific record. As a member of the Committee on Publication Ethics (COPE) the journal will follow the COPE guidelines on how to deal with potential acts of misconduct.
Authors should refrain from misrepresenting research results which could damage the trust in the journal, the professionalism of scientific authorship, and ultimately the entire scientific endeavour. Maintaining integrity of the research and its presentation can be achieved by following the rules of good scientific practice, which include:
  • The manuscript has not been submitted to more than one journal for simultaneous consideration.
  • The manuscript has not been published previously (partly or in full), unless the new work concerns an expansion of previous work (please provide transparency on the re-use of material to avoid the hint of text-recycling (“self-plagiarism”)).
  • A single study is not split up into several parts to increase the quantity of submissions and submitted to various journals or to one journal over time (e.g. “salami-publishing”).
  • No data have been fabricated or manipulated (including images) to support your conclusions
  • No data, text, or theories by others are presented as if they were the author’s own (“plagiarism”). Proper acknowledgements to other works must be given (this includes material that is closely copied (near verbatim), summarized and/or paraphrased), quotation marks are used for verbatim copying of material, and permissions are secured for material that is copyrighted.
    Important note: the journal may use software to screen for plagiarism.
  • Consent to submit has been received explicitly from all co-authors, as well as from the responsible authorities - tacitly or explicitly - at the institute/organization where the work has been carried out, before the work is submitted.
  • Authors whose names appear on the submission have contributed sufficiently to the scientific work and therefore share collective responsibility and accountability for the results.
  • Authors are strongly advised to ensure the correct author group, corresponding author, and order of authors at submission. Changes of authorship or in the order of authors are not accepted after acceptance of a manuscript.
  • Adding and/or deleting authors and/or changing the order of authors at revision stage may be justifiably warranted. A letter must accompany the revised manuscript to explain the reason for the change(s) and the contribution role(s) of the added and/or deleted author(s). Further documentation may be required to support your request.
  • Requests for addition or removal of authors as a result of authorship disputes after acceptance are honored after formal notification by the institute or independent body and/or when there is agreement between all authors.
  • Upon request authors should be prepared to send relevant documentation or data in order to verify the validity of the results. This could be in the form of raw data, samples, records, etc. Sensitive information in the form of confidential proprietary data is excluded.
If there is a suspicion of misconduct, the journal will carry out an investigation following the COPE guidelines. If, after investigation, the allegation seems to raise valid concerns, the accused author will be contacted and given an opportunity to address the issue. If misconduct has been established beyond reasonable doubt, this may result in the Editor-in-Chief’s implementation of the following measures, including, but not limited to:
  • If the article is still under consideration, it may be rejected and returned to the author.
  • If the article has already been published online, depending on the nature and severity of the infraction, either an erratum will be placed with the article or in severe cases complete retraction of the article will occur. The reason must be given in the published erratum or retraction note. Please note that retraction means that the paper is maintained on the platform, watermarked "retracted" and explanation for the retraction is provided in a note linked to the watermarked article.
  • The author’s institution may be informed.

Compliance with Ethical Standards 

To ensure objectivity and transparency in research and to ensure that accepted principles of ethical and professional conduct have been followed, authors should include information regarding sources of funding, potential conflicts of interest (financial or non-financial), informed consent if the research involved human participants, and a statement on welfare of animals if the research involved animals.
Authors should include the following statements (if applicable) in a separate section entitled “Compliance with Ethical Standards” when submitting a paper:
  • Disclosure of potential conflicts of interest
  • Research involving Human Participants and/or Animals
  • Informed consent
Please note that standards could vary slightly per journal dependent on their peer review policies (i.e. single or double blind peer review) as well as per journal subject discipline. Before submitting your article check the instructions following this section carefully.
The corresponding author should be prepared to collect documentation of compliance with ethical standards and send if requested during peer review or after publication.
The Editors reserve the right to reject manuscripts that do not comply with the above-mentioned guidelines. The author will be held responsible for false statements or failure to fulfill the above-mentioned guidelines.

Disclosure of potential conflicts of interest 

Authors must disclose all relationships or interests that could have direct or potential influence or impart bias on the work. Although an author may not feel there is any conflict, disclosure of relationships and interests provides a more complete and transparent process, leading to an accurate and objective assessment of the work. Awareness of a real or perceived conflicts of interest is a perspective to which the readers are entitled. This is not meant to imply that a financial relationship with an organization that sponsored the research or compensation received for consultancy work is inappropriate. Examples of potential conflicts of interests that are directly or indirectly related to the research may include but are not limited to the following:
  • Research grants from funding agencies (please give the research funder and the grant number)
  • Honoraria for speaking at symposia
  • Financial support for attending symposia
  • Financial support for educational programs
  • Employment or consultation
  • Support from a project sponsor
  • Position on advisory board or board of directors or other type of management relationships
  • Multiple affiliations
  • Financial relationships, for example equity ownership or investment interest
  • Intellectual property rights (e.g. patents, copyrights and royalties from such rights)
  • Holdings of spouse and/or children that may have financial interest in the work
In addition, interests that go beyond financial interests and compensation (non-financial interests) that may be important to readers should be disclosed. These may include but are not limited to personal relationships or competing interests directly or indirectly tied to this research, or professional interests or personal beliefs that may influence your research.
The corresponding author collects the conflict of interest disclosure forms from all authors. In author collaborations where formal agreements for representation allow it, it is sufficient for the corresponding author to sign the disclosure form on behalf of all authors. Examples of forms can be found
The corresponding author will include a summary statement in the text of the manuscript in a separate section before the reference list, that reflects what is recorded in the potential conflict of interest disclosure form(s).
See below examples of disclosures:
Funding: This study was funded by X (grant number X).
Conflict of Interest: Author A has received research grants from Company A. Author B has received a speaker honorarium from Company X and owns stock in Company Y. Author C is a member of committee Z.
If no conflict exists, the authors should state:
Conflict of Interest: The authors declare that they have no conflict of interest.

Research involving human participants and/or animals 

1) Statement of human rights

When reporting studies that involve human participants, authors should include a statement that the studies have been approved by the appropriate institutional and/or national research ethics committee and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
If doubt exists whether the research was conducted in accordance with the 1964 Helsinki Declaration or comparable standards, the authors must explain the reasons for their approach, and demonstrate that the independent ethics committee or institutional review board explicitly approved the doubtful aspects of the study.
The following statements should be included in the text before the References section:
Ethical approval: “All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”
Ethical approval retrospective studies
Although retrospective studies are conducted on already available data or biological material (for which formal consent may not be needed or is difficult to obtain) ethical approval may be required dependent on the law and the national ethical guidelines of a country. Authors should check with their institution to make sure they are complying with the specific requirements of their country.

2) Statement on the welfare of animals

The welfare of animals used for research must be respected. When reporting experiments on animals, authors should indicate whether the international, national, and/or institutional guidelines for the care and use of animals have been followed, and that the studies have been approved by a research ethics committee at the institution or practice at which the studies were conducted (where such a committee exists).
For studies with animals, the following statement should be included in the text before the References section:
Ethical approval: “All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.”
If applicable (where such a committee exists): “All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.”
If articles do not contain studies with human participants or animals by any of the authors, please select one of the following statements:
“This article does not contain any studies with human participants performed by any of the authors.”
“This article does not contain any studies with animals performed by any of the authors.”
“This article does not contain any studies with human participants or animals performed by any of the authors.”

Informed consent 

All individuals have individual rights that are not to be infringed. Individual participants in studies have, for example, the right to decide what happens to the (identifiable) personal data gathered, to what they have said during a study or an interview, as well as to any photograph that was taken. Hence it is important that all participants gave their informed consent in writing prior to inclusion in the study. Identifying details (names, dates of birth, identity numbers and other information) of the participants that were studied should not be published in written descriptions, photographs, and genetic profiles unless the information is essential for scientific purposes and the participant (or parent or guardian if the participant is incapable) gave written informed consent for publication. Complete anonymity is difficult to achieve in some cases, and informed consent should be obtained if there is any doubt. For example, masking the eye region in photographs of participants is inadequate protection of anonymity. If identifying characteristics are altered to protect anonymity, such as in genetic profiles, authors should provide assurance that alterations do not distort scientific meaning.
The following statement should be included:
Informed consent: “Informed consent was obtained from all individual participants included in the study.”
If identifying information about participants is available in the article, the following statement should be included:
“Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.”

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    Aims and Scope


    Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems

    The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized.

    Examples of subject areas that CBB publishes are:
    · biochemical and biophysical aspects of cell structure and function;
    · interactions of cells and their molecular/macromolecular constituents;
    · innovative developments in genetic and biomolecular engineering;
    · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular    assemblies;
    · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design

    For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.

    As to areas that we do not cover, we discourage clinical and epidemiological studies related to human health. We will consider papers on animal cell biology, but not plant species

    CBB also publishes reviews and minireviews, opinion papers, letters to the editor and proceedings of symposia.

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