Transparency in Biology

1. Front Matter

   Pages i-viii

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2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction to Transparency

      • Kohei Soga

      Pages 3-32

3. NIR-Fluorescence Imaging and Phosphors

   1. Front Matter

      Pages 33-33

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   2. Requirements of Nanostructures for Bioimaging Probes

      • Kohei Soga

      Pages 35-56

   3. Organic Dyes for NIR Imaging

      • Masao Kamimura

      Pages 57-71

   4. Semiconductor Quantum Dots for NIR Bioimaging

      • Masao Kamimura

      Pages 73-84

   5. Carbon Nanotubes—Potential of Use for Deep Bioimaging

      • Atsuto Onoda, Masakazu Umezawa

      Pages 85-107

   6. Rare-Earth-Doped Ceramic Nanoparticles for Transparency in the Biomedical Field

      • Karina Nigoghossian

      Pages 109-136

4. Application of NIR Light for Biomedical Photonics

   1. Front Matter

      Pages 137-137

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   2. Nanothermometry for Deep Tissues by Using Near-Infrared Fluorophores

      • Masakazu Umezawa, Karina Nigoghossian

      Pages 139-166

   3. Computed Tomography

      • Toshihiro Sera

      Pages 167-187

5. Application of NIR Light for Medical Photonics

   1. Front Matter

      Pages 189-189

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   2. NIR Light Induced Photodynamic Therapy

      • Masao Kamimura

      Pages 191-201

   3. NIR Hyperspectral Imaging

      • Kyohei Okubo

      Pages 203-222

   4. Multimodal Imaging with NIR Light

      • Thi Kim Dung Doan

      Pages 223-263

This book explains transparency in biology with emphasis on bending and absorption, which together are the essence of transparency. The reader is provided with an understanding of why the interior of the body can be made to appear transparent through the application of elementary physics. Based on the principle of transparency, emerging imaging techniques using near-infrared light to view the body transparently are explained with examples such as cancer detection and temperature imaging of deep tissues. This book is useful to many researchers, including biologists, physicists, chemists, materials scientists, and device engineers as well as developers—all who seek a deep understanding of transparency in bioimaging.

• less invasive diagnosis
• near infrared photonics
• optical clearing in biology
• deep imaging of live tissue
• scattering by biological tissue

• Materials Science and Technology, Tokyo University of Science, Tokyo, Japan

  Kohei Soga, Masakazu Umezawa, Kyohei Okubo

Kohei Soga started his research on rare-earth-doped luminescent materials in 1990 as a graduate student of the University of Tokyo. His thesis concentrated on relating the spectroscopic properties of the rare-earth ions and the structure of the host glass. After obtaining his Ph.D. degree in 1995, he expanded his research onto the photonic applications, especially on that relating to optical communication. Since 2004, he has focussed his research on the interdisciplinary fields of bio- and nano-photonics with the aim to develop a biophotonic system with near-infrared excitation.


Masakazu Umezawa received his M.Pharm. (2008) and Ph.D. (2010) degrees under the supervision of Prof. Ken Takeda in Pharmaceutical Sciences from Tokyo University of Science. He worked as a Postdoctoral Fellow, Assistant Professor, and Junior Associate Professor until 2016 and then joined the Department of Materials Science and Technology, Tokyo University of Science, as a Project Research Associate to promote the research on “deeper and precise fluorescence bioimaging through the second biological window (SBW)” supervised by Prof. Kohei Soga. His research interests are “nano-bio” interactions for the designing of safer and functionalized nanomaterials and their biomedical applications.


Kyohei Okubo received his M.E. and Ph.D. degrees from the University of Tsukuba, Japan, in 2014 and 2017, respectively. From 2017 to 2018, he has worked in the University of Tokyo as Japanese Society of Promotion and Science (JSPS) Postdoctoral Researcher. In 2018, he joined the Department of Materials Science and Technology, Tokyo University of Science, as an Assistant Professor. He is currently involved in the development of near-infrared bioimaging and biomedical devices.

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