Overview
- Updating the latest understanding of immune cell functions, cancer progression, infection, and inflammation using single-cell DNA or RNA sequencing
- Exploring roles of target gene methylations in the pathogenesis of diseases
- Focusing on the clinical applications of single cell sequencing and DNA methylation techniques
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1255)
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Table of contents (19 chapters)
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Front Matter
Keywords
About this book
With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
Editors and Affiliations
About the editors
Buwei Yu, MD, PhD, is a Professor at the Department of Anesthesiology，Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, and President of the Chinese Medical Doctor Association and the Society of Anaesthesiologists.
Jiaqiang Zhang, MD, PhD, is a Professor and Director of the Department of Anaesthesiology and Perioperative Medicine, Henan Provincial People’s Hospital, and a member of the Chinese Medical Association’s Anaesthesia Branch, and the National Committee of the Anaesthesia Branch of the Chinese Medical Association. He is also Vice Chairman of the Anaesthesia Branch of the Henan Medical Association. His main research focuses include investigating the mechanisms of postoperative cognitive dysfunction, clinical bioinformatics, anesthesia and neurodevelopment, and the physiology of pain. He is the author of more than 150 scientific publications.
Yiming Zeng is a Professor of Respiratory Medicine, Chairman of the Academic Committee of the Second Affiliated Hospital of Fujian Medical University, State Council Expert for Special Allowance, and Director of Fujian Province’s Sleep Medicine Key Laboratory. He was named a middle-aged expert with outstanding contributions from the National Health and Family Planning Commission of the People's Republic of China (NHFPC). His main research focuses include clinical interventional pulmonology; sleep-breathing disorders; and non-invasive mechanical ventilation. He is the author of more than 150 scientific publications.
Li Li is the Director of Department of Science Research and Discipline Construction, and Principle Investigator of the Clinical Centre of Single-Cell Biomedicine, Henan Provincial People's Hospital. She is a member of clinical research group of the Chinese Medical Association’s Scientific Research Management Branch, and of the Standing Committee of the Chinese Medical Association’s Henan Research and Management Branch. Further, sheis Vice-chairman of Henan Discipline Management Branch of the Chinese Hospital Management Society. She has been engaged in the management of medical scientific research for 30 years, with a focus on big data, laboratory biosafety and medical ethics. She published more than 20 scientific papers.
Xiangdong Wang, MD, PhD, is a Distinguished Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Executive Director of Clinical Science Institute of Fudan University Zhongshan Hospital, Director of Fudan University Center of Clinical Bioinformatics, and Deputy Director of Shanghai Respiratory Research Institute. He is also a Visiting Professor at King’s College London. His main research focuses on clinical bioinformatics, disease-specific biomarkers, chronic lung diseases, cancer immunology, and molecular and cellular therapies. He is the author of more than 300 scientific publications.
Bibliographic Information
Book Title: Single-cell Sequencing and Methylation
Book Subtitle: Methods and Clinical Applications
Editors: Buwei Yu, Jiaqiang Zhang, Yiming Zeng, Li Li, Xiangdong Wang
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-15-4494-1
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2020
Hardcover ISBN: 978-981-15-4493-4Published: 20 September 2020
Softcover ISBN: 978-981-15-4496-5Published: 21 September 2021
eBook ISBN: 978-981-15-4494-1Published: 19 September 2020
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 247
Number of Illustrations: 3 b/w illustrations, 114 illustrations in colour
Topics: Molecular Medicine, Bioinformatics, Cancer Research