Overview
This book is first of its kind that summarizes the role of the 18 isoforms of Histone deacetylase (HDAC) in different neurodegenerative disorders
It uniquely highlights the potential of various HDAC inhibitors as therapeutic agents against different neurological disorders
It provides an updated account of the various approaches to design the selective inhibitors as targets against Classical HDACs
It comprehensively enriches the understanding of the synergistic therapeutic approaches for mitigating the dose limited effects of HDAC inhibitors
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Table of contents (10 chapters)
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Front Matter
Keywords
About this book
This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders.
The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.
Authors and Affiliations
About the author
Dr. Shabir Ahmad Ganai is currently working as Assistant Professor Cum Junior Scientist, Division of Basic Sciences and Humanities, Faculty of Agriculture, SKUAST-Kashmir, Wadura, Sopore, 193201, Jammu & Kashmir, India. He has done his masters in Biochemistry from Bangalore University (2005-2007) and earned his Ph.D. from elite SASTRA University (2009-2014). Later, he did his post-doctorate from National Brain Research Centre, Haryana, India. He has also served as research fellow in SKUAST-Kashmir. His research interests are focused on understanding the modulations of the nuclear geometry and post-translational modifications during treatment with structurally distinct HDAC inhibitors. He has been actively involved in designing the target-selective inhibitors against Class II HDACs using various bioinformatics tools.
Dr. Shabir Ahmad Ganai has published more than 20 research articles and one editorial in high impact factor international Journals. He has also served as guest editor for a thematic issue (Epigenetics: A novel frontier for drug discovery) published by Current Medicinal Chemistry. In addition, he serves as a referee for many reputed international journals like Current Drug Targets, PLOS ONE and Medicinal Chemistry Research. He is an active member of many national and international societies including, The International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT).
Bibliographic Information
Book Title: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders
Authors: Shabir Ahmad Ganai
DOI: https://doi.org/10.1007/978-981-13-8019-8
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-8018-1Published: 15 July 2019
Softcover ISBN: 978-981-13-8021-1Published: 15 August 2020
eBook ISBN: 978-981-13-8019-8Published: 02 July 2019
Edition Number: 1
Number of Pages: XVII, 93
Number of Illustrations: 3 b/w illustrations, 5 illustrations in colour
Topics: Neurosciences, Pharmacology/Toxicology, Genetics and Genomics, Protein Science, Posttranslational Modification