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Results and Problems in Cell Differentiation

Human Neural Stem Cells

From Generation to Differentiation and Application

Editors: Buzanska, Leonora (Ed.)

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  • Summarizes the most recent advances in human neural stem cells (hNSC) research
  • Presents hNSC derivation methods
  • Discusses mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action
  • Outlines therapeutic potential of human neural stem cells 
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eBook $139.00
price for Mexico (gross)
  • ISBN 978-3-319-93485-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for Mexico
  • ISBN 978-3-319-93484-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action.

The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.


Table of contents (14 chapters)

Table of contents (14 chapters)
  • Derivation of Neural Stem Cells from the Developing and Adult Human Brain

    Kelly, Claire M. (et al.)

    Pages 3-20

  • Human Somatic Stem Cell Neural Differentiation Potential

    Eve, David J. (et al.)

    Pages 21-87

  • Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury

    Jendelova, Pavla (et al.)

    Pages 89-102

  • Generation of Human Neural Stem Cells by Direct Phenotypic Conversion

    Kwon, Daekee (et al.)

    Pages 103-121

  • Epigenetic Regulation of Human Neural Stem Cell Differentiation

    Honda, Mizuki (et al.)

    Pages 125-136

Buy this book

eBook $139.00
price for Mexico (gross)
  • ISBN 978-3-319-93485-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for Mexico
  • ISBN 978-3-319-93484-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Human Neural Stem Cells
Book Subtitle
From Generation to Differentiation and Application
Editors
  • Leonora Buzanska
Series Title
Results and Problems in Cell Differentiation
Series Volume
66
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-93485-3
DOI
10.1007/978-3-319-93485-3
Hardcover ISBN
978-3-319-93484-6
Series ISSN
0080-1844
Edition Number
1
Number of Pages
XI, 329
Number of Illustrations
1 b/w illustrations, 40 illustrations in colour
Topics