The Gut Microbiome in Health and Disease

1. Front Matter

   Pages i-viii

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2. Intestinal Microbiome in Health and Disease: Introduction

   • Dirk Haller

   Pages 1-3

3. Composition and Function of the Gut Microbiome

   • Michael Blaut

   Pages 5-30

4. Microbiome and Early Life

   • Mathias Hornef

   Pages 31-47

5. Molecular Microbiome Analysis

   • Amélia Camarinha-Silva, W. Florian Fricke

   Pages 49-65

6. Evolutionary Perspectives on the Human Gut Microbiome

   • Shauni Doms, Britt-Marie Hermes, John F. Baines

   Pages 67-78

7. Microbiome and Diet

   • Francesca De Filippis, Danilo Ercolini

   Pages 79-88

8. Microbiome and Gut Immunity: The Epithelium

   • Claudia Günther

   Pages 89-102

9. Microbiome and Gut Immunity: Innate Immune Cells

   • Till Strowig, Sophie Thiemann, Andreas Diefenbach

   Pages 103-118

10. Microbiome and Gut Immunity: T Cells

    • Joern Pezoldt, Juhao Yang, Mangge Zou, Jochen Huehn

    Pages 119-140

11. Microbiome and Gut Immunity: B Cells

    • Oliver Pabst

    Pages 141-150

12. Microbiome and Diseases: Inflammatory Bowel Diseases

    • Kai Hildner, Nadine Waldschmitt, Dirk Haller

    Pages 151-174

13. Microbiome and Diseases: Allergy

    • Florian Wölbing, Martin Köberle, Thomas Volz, Tilo Biedermann

    Pages 175-194

14. Microbiome and Diseases: Graft-Versus-Host Disease

    • D. Weber, E. Holler

    Pages 195-208

15. Microbiome and Diseases: Pathogen Infection

    • Christine Josenhans, Guntram A. Grassl

    Pages 209-230

16. Microbiome and Diseases: Colorectal Cancer

    • Amina Iftekhar, Andreas Sperlich, Klaus-Peter Janssen, Michael Sigal

    Pages 231-249

17. Microbiome and Diseases: Metabolic Disorders

    • Thomas Clavel, Josef Ecker

    Pages 251-277

18. Microbiome and Diseases: Hepatic Disorders

    • Ina Bergheim, Detlef Schuppan

    Pages 279-293

19. Microbiome and Diseases: Neurological Disorders

    • Anne E. Slingerland, Christoph K. Stein-Thoeringer

    Pages 295-310

20. Clinical Implementation of High-Throughput Sequencing

    • Andreas Hiergeist, André Gessner

    Pages 311-325

The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

• Clinical applications
• Innate immunology
• Intestinal microbiome
• Metabolic diseases
• Probiotics

• Chair of Nutrition and Immunology, Technical University Munich, Freising, Germany

  Dirk Haller

Dr. Dirk Haller is Full Professor for Nutrition and Immunology and Director of the Institute for Food & Health at the Technical University of Munich. He received his academic training at the University of Hohenheim, graduating in Nutrition Science and Food Technology, and completed his PhD in Microbiology and Immunology. Following periods of post-doctorial research in Switzerland (Nestlé Research Center) and USA (University of North Carolina at Chapel Hill), he received carreer and science awards from the German Research Foundation (DFG)  and the German Society of Medical Microbiology (DGHM). He pioneered the concept of microbe-host interactions and substantially contributed to the understanding of chronic inflammatory disorders in the gut.

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