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  • © 2017

Nitrite and Nitrate in Human Health and Disease

  • Chapters in new edition are fully updated with information from the latest research findings
  • New edition includes chapters on nitrite and nitrate and age medicine, hypertension, and exercise performance
  • Evidence-based chapters with detailed citations
  • Comprehensive coverage of nitrate and nitrite and human health, from a basic understanding of the biochemistry, to environmental factors, to therapeutic applications
  • Each chapter begins with detailed key points summarizing the major topics
  • Includes supplementary material: sn.pub/extras

Part of the book series: Nutrition and Health (NH)

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Hardcover Book USD 139.99
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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xxxi
  2. Biochemistry, Molecular Biology, Metabolism and Physiology

    1. Front Matter

      Pages 1-1
    2. Introduction

      • Nathan S. Bryan, Joseph Loscalzo
      Pages 3-10
    3. From Atmospheric Nitrogen to Bioactive Nitrogen Oxides

      • Mark Gilchrist, Nigel Benjamin
      Pages 11-19
    4. Nitrate-Reducing Oral Bacteria: Linking Oral and Systemic Health

      • Nathan S. Bryan, Joseph F. Petrosino
      Pages 21-31
    5. Epigenetics and the Regulation of Nitric Oxide

      • Diane E. Handy, Joseph Loscalzo
      Pages 33-52
    6. The Mitochondrion: A Physiological Target of Nitrite

      • Danielle A. Guimaraes, Chris Reyes, Sruti Shiva
      Pages 53-68
    7. Sources of Exposure to Nitrogen Oxides

      • Andrew L. Milkowski
      Pages 69-82
  3. Food and Environmental Exposures to Nitrite and Nitrate

    1. Front Matter

      Pages 83-83
    2. History of Nitrite and Nitrate in Food

      • Jimmy T. Keeton
      Pages 85-97
    3. Nutritional Epidemiology of Nitrogen Oxides: What Do the Numbers Mean?

      • Martin Lajous, Walter C. Willett
      Pages 99-109
    4. Nutritional Impact on the Nitric Oxide Pathway

      • Wing Tak Wong, John P. Cooke
      Pages 111-128
    5. Nitrite and Nitrate in Human Breast Milk: Implications for Development

      • Pamela D. Berens, Nathan S. Bryan
      Pages 141-152
  4. Nitrite and Nitrate in Therapeutics and Disease

    1. Front Matter

      Pages 163-163
    2. Nitric Oxide Signaling in Health and Disease

      • Nathan S. Bryan, Jack R. Lancaster Jr.
      Pages 165-178
    3. Inhaled Nitric Oxide

      • Kenneth D. Bloch, Andrea U. Steinbicker, Lisa Lohmeyer, Rajeev Malhotra
      Pages 179-193
    4. Pharmacology of Nitrovasodilators

      • Thomas Münzel, Andreas Daiber
      Pages 195-216
    5. Nitrite and Nitrate in Ischemia–Reperfusion Injury

      • David J. Lefer, Nathan S. Bryan, Chelsea L. Organ
      Pages 217-234

About this book

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references.

The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function.

Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

Editors and Affiliations

  • Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA

    Nathan S. Bryan

  • Department of Medicine, Harvard Medical School, Boston, USA

    Joseph Loscalzo

About the editors

Nathan S. Bryan, PhD
Assistant Professor
Institute of Molecular Medicine
The University of Texas health Science Center at Houston
Houston, TX

Joseph Loscalzo, MD, PhD
Hersey Professor of the Theory and Practice of Medicine
Harvard Medical School;
Chairman, Department of Medicine
Brigham and Women’s Hospital;
President,
Brigham Medical Research and Education Foundation, Inc.,
Boston, MA, USA

Bibliographic Information

  • Book Title: Nitrite and Nitrate in Human Health and Disease

  • Editors: Nathan S. Bryan, Joseph Loscalzo

  • Series Title: Nutrition and Health

  • DOI: https://doi.org/10.1007/978-3-319-46189-2

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-46187-8Published: 10 February 2017

  • Softcover ISBN: 978-3-319-83463-4Published: 17 July 2018

  • eBook ISBN: 978-3-319-46189-2Published: 31 January 2017

  • Series ISSN: 2628-197X

  • Series E-ISSN: 2628-1961

  • Edition Number: 2

  • Number of Pages: XXXI, 349

  • Number of Illustrations: 13 b/w illustrations, 35 illustrations in colour

  • Topics: Clinical Nutrition, Medical Biochemistry, Ecotoxicology

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access