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RNA Technologies

Modified Nucleic Acids in Biology and Medicine

Editors: Jurga, Stefan, Erdmann (Deceased), Volker A., Barciszewski, Jan (Eds.)

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  • Solves problems in the analysis of structure and functions of genetic material
  • Equips readers to handle complex diagnostic methods
  • Covers different applications of nucleic acids
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eBook $169.00
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  • ISBN 978-3-319-34175-0
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  • ISBN 978-3-319-81693-7
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About this book

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties.

The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.

Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides.

This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

 

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Transfer RNA Modifications: From Biological Functions to Biomedical Applications

    Pages 1-26

    Torres, Adrian Gabriel (et al.)

  • Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications

    Pages 27-54

    Lyons, Shawn M. (et al.)

  • Sulfur Modifications in tRNA: Function and Implications for Human Disease

    Pages 55-71

    Shigi, Naoki

  • Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, a Thermophilic Eubacterium

    Pages 73-89

    Hori, Hiroyuki (et al.)

  • Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health

    Pages 91-130

    Frohlich, Kyla M. (et al.)

Buy this book

eBook $169.00
price for Mexico
  • ISBN 978-3-319-34175-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for Mexico
  • ISBN 978-3-319-34173-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for Mexico
  • ISBN 978-3-319-81693-7
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Modified Nucleic Acids in Biology and Medicine
Editors
  • Stefan Jurga
  • Volker A. Erdmann (Deceased)
  • Jan Barciszewski
Series Title
RNA Technologies
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-34175-0
DOI
10.1007/978-3-319-34175-0
Hardcover ISBN
978-3-319-34173-6
Softcover ISBN
978-3-319-81693-7
Series ISSN
2197-9731
Edition Number
1
Number of Pages
XIV, 453
Number of Illustrations
76 b/w illustrations, 46 illustrations in colour
Topics

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