Recent Advances in Stem Cells

1. Front Matter

   Pages i-xiii

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2. Ethics and Patents in Stem Cell Research

   • Elina Davé, Na Xu, Neil Davey, Sonya Davey

   Pages 1-13

3. Stem Cells for Drug Screening

   • Hee Young Kang, Eui-Bae Jeung

   Pages 15-41

4. Genome Editing in Human Pluripotent Stem Cells

   • Liuhong Cai, Yoon-Young Jang, Zhaohui Ye

   Pages 43-67

5. Pluripotent Stem Cells for Kidney Diseases

   • Navin R. Gupta, Albert Q. Lam

   Pages 69-84

6. Pluripotent Stem Cells for Modeling Motor Neuron Diseases

   • Delphine Bohl

   Pages 85-100

7. Pluripotent Stem Cell-Derived Pancreatic β Cells: From In Vitro Maturation to Clinical Application

   • Essam M. Abdelalim, Mohamed M. Emara

   Pages 101-129

8. Clinical Applications of Induced Pluripotent Stem Cells in Cancer

   • Teresa de Souza Fernandez, André Luiz Mencalha, Cecília de Souza Fernandez

   Pages 131-158

9. Banking of Human Umbilical Cord Blood Stem Cells and Their Clinical Applications

   • Dunia Jawdat

   Pages 159-177

10. Interactions Between Multipotential Stromal Cells (MSCs) and Immune Cells During Bone Healing

    • Jehan J. El-Jawhari, Elena Jones, Dennis McGonagle, Peter V. Giannoudis

    Pages 179-211

11. Bone Marrow Stromal Stem Cells for Bone Repair: Basic and Translational Aspects

    • Basem M. Abdallah, Asma Al-Shammary, Hany M. Khattab, Abdullah AlDahmash, Moustapha Kassem

    Pages 213-232

12. Neural Crest Stem Cells: A Therapeutic Hope Machine for Neural Regeneration

    • Ahmed El-Hashash

    Pages 233-250

13. Lung Stem Cells and Their Use for Patient Care: Are We There Yet?

    • Ahmed E. Hegab, Tomoko Betsuyaku

    Pages 251-263

14. Back Matter

    Pages 265-269

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This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications.  The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer;  ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells.


Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.

• cartilage repair
• cord banking
• hematopoiesis
• pluripotent
• stem cell-derived

• Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar

  Essam M. Abdelalim

Dr. Essam M. Abdelalim is a Scientist at Qatar Biomedical Research Institute (QBRI) in Doha, Qatar and an Assistant Professor at Hamad Bin Khalifa University (HBKU) in that city. He is also Associate Professor at the Suez Canal University in Ismailia, Egypt, where he received his B.Sc. degree and his M.Sc. degree. He received his Ph.D. in Medical Science from Shiga University of Medical Science in Otsu, Japan and was later appointed Assistant Professor at that university. Dr. Abdelalim was awarded a Postdoctoral Fellowship from the Japan Society for Promotion of Science, where he studied the roles of natriuretic peptides and p53 in the regulation of self-renewal, pluripotency, and differentiation of embryonic stem cells (ESCs).


Dr. Abdelalim’s research interests focus on understanding the molecular mechanisms controlling unique characteristics of pluripotent stem cells (PSCs) and establishing their differentiation into specific cell types. His current research focuses on the potential use of PSCs to study diabetes, insulin resistance, and pancreatic beta cell development.

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