Nanocarriers for Drug Delivery

1. Front Matter

   Pages i-x

   PDF

2. Polymeric Nanoparticles

   • Marcela Tavares Luiz, Juliana Palma Abriata, Giovanni Loureiro Raspantini, Juliana Maldonado Marchetti

   Pages 1-17

3. Lipid Nanocarriers

   • Mariza A. Miranda, Margarete M. de Araujo, Alexandre R. Gaspari, Leticia B. Silva, Ivana P. S. Carvalho, Jacqueline C. L. Campos et al.

   Pages 19-47

4. Inorganic Nanoparticles for Biomedical Applications

   • Paula M. P. Lins, Laís Ribovski, Isabella Sampaio, Olavo A. Santos, Valtencir Zucolotto, Juliana Cancino-Bernardi

   Pages 49-72

5. Colloidal Disperse Systems: Microemulsions and Nanoemulsions

   • Andreia Ascenso, Sandra Simões, Joana Marto, Helena Margarida Ribeiro, António José Almeida

   Pages 73-81

6. Physicochemical Characterization of Drug Nanocarrriers

   • Giovanni Loureiro Raspantini, Marcela Tavares Luiz, Melanie Tavares, Eduardo Ricci-Junior

   Pages 83-105

7. Targeting of Drug Nanocarriers

   • Josimar O. Eloy, Raquel Petrilli, Robert J. Lee

   Pages 107-126

8. Nanocarriers for Oral Drug Delivery

   • Beatriz Stringhetti Ferreira Cury, Andréia Bagliotti Meneguin, Fabíola Garavello Prezotti, Fernanda Isadora Boni, Valeria Maria de Oliveira Cardoso

   Pages 127-151

9. Nanocarriers of Drugs for Topical Delivery

   • Maria Teresa Junqueira Garcia, Luciana Biagini Lopes, Gislaine Ribeiro Pereira, Newton Andréo-Filho

   Pages 153-181

10. Recent Advances in Nanocarriers Used for Selective Gene Silencing Therapy

    • Fabíola Silva Garcia Praça, Lívia Neves Borgheti-Cardoso, Margarete Moreno de Araújo, Maria Vitória Lopes Badra Bentley

    Pages 183-221

11. Nanocarriers for the Diagnosis and Treatment of Cancer

    • Bruno Fonseca-Santos, Patrícia Bento da Silva, Josimar O. Eloy, Marlus Chorilli

    Pages 223-252

12. Nanosystems Comprising Biocompatible Polymers for the Delivery of Photoactive Compounds in Biomedical Applications

    • Antonio Claudio Tedesco, Fernando Lucas Primo, Raquel Petrilli

    Pages 253-287

13. Toxicology of Nanoparticles

    • Patrícia Mazureki Campos, Juliana Palma Abriata, Priscyla D. Marcato

    Pages 289-318

14. Regulation of Nanotechnology-Based Products Subject to Health Regulations: Application of Quality by Design (QbD) and Quality Risk Management (QRM)

    • André Luís Dias, Natália Noronha Ferreira, Leonardo Miziara Barboza Ferreira, Liliane Neves Pedreiro, Aline Martins dos Santos, Maria Palmira Daflon Gremião

    Pages 319-347

This book covers basic aspects of different nanoparticles, including type of materials, lipid, polymeric and inorganic structures, synthesis strategies, as well as the main physicochemical characterization techniques. Moreover, this book addresses applications for both treatment and diagnosis of diseases, highlighting in vitro and in vivo findings and clinical evaluation. The chapters highlight the main barriers for drug delivery which can benefit from nanoencapsulation: the topical and oral routes. The main innovations in the field, such as gene therapy and functionalization of nanoparticles with a variety of moieties, including monoclonal antibodies for selective delivery, are discussed and illustrated with examples. Finally, the application of nanoparticles for drug delivery to cancer is reviewed considering toxicology and regulatory aspects.

• Nanotechnology
• Drugs
• Pharmacy
• Diagnosis of Cancer
• Nanoparticles

• Faculty of Pharmacy, Odontology and Nursing, Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil

  Josimar O. Eloy

• Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, University of Sao Paulo, Ribeirão Preto, Brazil

  Juliana Palma Abriata, Juliana Maldonado Marchetti

Josimar Eloy is a Professor at the Federal University of Ceará (UFC), in Fortaleza, Brazil, working in the area of pharmaceutical technology and nanotechnology. His current research involves the strategy of functionalization of drug nanocarriers for targeting, evaluated in models in vitro (cytotoxicity and cell uptake by flow cytometry and confocal microscopy) and in vivo, using xenograft models in mice for breast cancer and prostate cancer.

Juliana Abriata is a postdoc student at the School of Pharmaceutical Sciences of Ribeirao Preto, Sao Paulo, Brazil. Her research work focuses on development, characterization (drug quantification by HPLC, particle size by dynamic light scattering, in vitro release studies, calorimetric analysis, DSC and TGA, infrared spectroscopy, scanning and transmission electron microscopy) and evaluation of nanocarrier systems for ovarian cancer therapy and Chagas disease.

JulianaMarchetti is an Associated Professor of the Department of Pharmaceutical Sciences at School of Pharmaceutical Sciences of Ribeirao Preto, USP, working in the pharmacy area with an emphasis on Pharmaceutical Technology and Nanotechnology. Her research focus on the development and evaluation of systemic delivery systems, whose objectives include the development, characterization and evaluation of polymeric micro- and nanoparticles, long-circulation micelles, liposomes, thermoreversible gels, complexes with cyclodextrins and with dendrimers aiming at the optimization of Cancer Therapy, Chagas Disease, Tuberculosis and Hormone Replacement Therapy. She is an expert on spectroscopic, calorimetric, microscopic techniques (Scanning Electron Microscopy), evaluation of rheological behavior, in vitro (dissolution and release and biodegradation studies) and in vivo (histocompatibility, bioavailability, biodistribution and anti-tumor activity) assays.

Policies and ethics