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Pathophysiology of Obesity-Induced Health Complications

  • Book
  • © 2020

Overview

Editors:
  1. Paramjit S. Tappia

    1. Asper Clinical Research Institute and Office of Clinical Research, St. Boniface Hospital, Winnipeg, Canada

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  2. Bram Ramjiawan

    1. Asper Clinical Research Institute and Office of Clinical Research, St. Boniface Hospital, Winnipeg, Canada

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  3. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Canada

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  • Brings together an outline of the link between obesity and the onset of many adverse health conditions
  • Highlight the compendium of adverse consequences of obesity to human health and to provide current understanding of the cellular and biochemical mechanisms of obesity induced health complications
  • Covers a broad range of topics related to the mechanisms of obesity-induced health complications

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 19)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvi
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  2. General Aspects of Obesity and Health Complications

    1. Front Matter

      Pages 1-1
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    2. Prevalence, Consequences, Causes and Management of Obesity

      • Paramjit S. Tappia, Danielle Defries
      Pages 3-22

    3. Adipocytes Under Environmental Assault: Targets for Obesity?

      • Shalini Behl, Jaipaul Singh
      Pages 23-41

    4. Obesity and Its Complications Pathogenesis

      • Isabella So, Hariom Yadav
      Pages 43-56

  3. Metabolic Disturbances and Inflammation Due to Obesity

    1. Front Matter

      Pages 57-57
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    2. Extracellular Vesicles and Circulating miRNAs—Exercise-Induced Mitigation of Obesity and Associated Metabolic Diseases

      • Patience Oluchukwu Obi, Benjamin Bydak, Adeel Safdar, Ayesha Saleem
      Pages 59-80

    3. Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance

      • Gaurav Gupta, Ridhima Wadhwa, Parijat Pandey, Sachin Kumar Singh, Monica Gulati, Saurabh Sajita et al.
      Pages 81-97

    4. Obesity and Osteoarthritis: Are Adipokines Bridging Metabolism, Inflammation, and Biomechanics?

      • Vera Francisco, Clara Ruiz-Fernández, Jesús Pino, Antonio Mera, Miguel Angel Gonzalez-Gay, Francisca Lago et al.
      Pages 99-115

    5. Understanding the Initiation and Progression of Diet-Induced Obesity and Associated Pathophysiology: Lessons Learned from a Rat Model

      • David A. Hart, Walter Herzog, Jaqueline L. Rios, Raylene A. Reimer, Kelsey H. Collins
      Pages 117-133

    6. Immune Modulation and Macrophage Polarization in the Pathogenesis of Pancreatic Dysfunction and Obesity

      • Nuray Yazihan, Sevginur Akdas
      Pages 135-151

  4. Neurological and Visceral Complications Due to Obesity

    1. Front Matter

      Pages 153-153
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    2. Association Between Obesity and Poor Sleep: A Review of Epidemiological Evidence

      • Yaqoot Fatima, Abdullah Al Mamun, Timothy Skinner
      Pages 155-167

    3. Exploration of the Bidirectionality of Obesity and Depression by Means of the Neuropsychological Model of Obesity Genesis

      • Matthew Ramjiawan, Paramjit S. Tappia
      Pages 169-180

    4. Obesity-Induced Non-alcoholic Fatty Liver Disease (NAFLD): Role of Hyperhomocysteinemia

      • Santosh Kumar, Sreyoshi F. Alam, Paul K. Ganguly
      Pages 181-192

    5. Mechanisms for Obesity Related Kidney Disease

      • Praveen Murlidharan, Sreelekshmi Kamaladevan, Satish Balan, Chandrasekharan C. Kartha
      Pages 193-216

    6. Consequences of Maternal Obesity on Neonatal Outcomes and Cardio-Metabolic Health in Infancy

      • Delphine Mitanchez, Pascale Chavatte-Palmer
      Pages 217-239

    7. The Developmental Mechanisms of Obesity by Maternal Obesity

      • Long T. Nguyen, Carol A. Pollock, Sonia Saad
      Pages 241-254

    8. Diet Induced Maternal Hypercholesterolemia and In Utero Fetal Programming

      • V. S. Jayalekshmi, Surya Ramachandran
      Pages 255-268

  5. Strategies for the Prevention of Obesity-Induced Complications

    1. Front Matter

      Pages 269-269
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Keywords

About this book

​According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a  number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. 


The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. 


Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The firstsection serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.

Editors and Affiliations

  • Asper Clinical Research Institute and Office of Clinical Research, St. Boniface Hospital, Winnipeg, Canada

    Paramjit S. Tappia, Bram Ramjiawan

  • Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Canada

    Naranjan S. Dhalla

Bibliographic Information

  • Book Title: Pathophysiology of Obesity-Induced Health Complications

  • Editors: Paramjit S. Tappia, Bram Ramjiawan, Naranjan S. Dhalla

  • Series Title: Advances in Biochemistry in Health and Disease

  • DOI: https://doi.org/10.1007/978-3-030-35358-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-35357-5Published: 18 January 2020

  • Softcover ISBN: 978-3-030-35360-5Published: 18 January 2021

  • eBook ISBN: 978-3-030-35358-2Published: 17 January 2020

  • Series ISSN: 2512-2142

  • Series E-ISSN: 2512-2150

  • Edition Number: 1

  • Number of Pages: XVI, 345

  • Number of Illustrations: 9 b/w illustrations, 31 illustrations in colour

  • Topics: Human Physiology

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