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Human Perspectives in Health Sciences and Technology

Approaching Complex Diseases

Network-Based Pharmacology and Systems Approach in Bio-Medicine

Editors: Bizzarri, Mariano (Ed.)

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  • The first book to systematically cover the issue of how to integrate network biology, systems biology and polypharmacology
  • The only book dealing with the proposal of a paradigm shift in drug discovery focused on the network pharmacology
  • Brings together a group of top scholars on the much-debated issue of Systems-oriented drug design
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  • ISBN 978-3-030-32857-3
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About this book

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.


About the authors

Mariano Bizzarri PhD, M.D., is Associate Professor of Clinical Pathology in the Department of Experimental Medicine at University Sapienza, Rome (Italy). He was appointed as member of the Italian Space Agency (ASI) Scientific Committee in 2005 and he was elected President of that Committee in 2011-2014. He is a co-founder of the Italian Society for Space Biomedicine and Biochemistry (2006). Head of the Interdepartmental Systems Biology Center and member of the Space Research Interdepartmental Center of the University La Sapienza (CRAS). He is the Editor in Chief of the international journal ORGANISMS. He has authored hundreds of scientific and philosophical essays, as well as of dozen of scientific books, among which Systems Biology (Springer protocols, 2017). 

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Revisiting the Concept of Human Disease

    Pages 1-34

    Bizzarri, Mariano (et al.)

  • Dynamical Aspects of Pharmacokinetic/Pharmacodynamic & Quantitative Systems Pharmacology Models

    Pages 35-61

    Loisios-Konstantinidis, Ioannis (et al.)

  • The Efficiency of Multi-target Drugs: A Network Approach

    Pages 63-75

    Alberca, Lucas N. (et al.)

  • Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases

    Pages 77-94

    Alves, Vinicius M. (et al.)

  • Big Data, Personalized Medicine and Network Pharmacology: Beyond the Current Paradigms

    Pages 95-110

    Giuliani, Alessandro (et al.)

Buy this book

eBook $189.00
price for Mexico
  • ISBN 978-3-030-32857-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for Mexico
  • ISBN 978-3-030-32856-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Approaching Complex Diseases
Book Subtitle
Network-Based Pharmacology and Systems Approach in Bio-Medicine
Editors
  • Mariano Bizzarri
Series Title
Human Perspectives in Health Sciences and Technology
Series Volume
2
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-32857-3
DOI
10.1007/978-3-030-32857-3
Hardcover ISBN
978-3-030-32856-6
Series ISSN
2661-8915
Edition Number
1
Number of Pages
XVI, 483
Number of Illustrations
8 b/w illustrations, 41 illustrations in colour
Topics

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