Advances in Experimental Medicine and Biology

Direct Mechanisms in Cholesterol Modulation of Protein Function

Editors: Rosenhouse-Dantsker, Avia, Bukiya, Anna N. (Eds.)

Free Preview
  • Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function
  • Contributors are well-known experts in their fields and provide international perspective
  • Research will be invaluable across several areas from biochemistry to nutrition
see more benefits

Buy this book

eBook $129.00
price for Mexico (gross)
  • ISBN 978-3-030-14265-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for Mexico
  • ISBN 978-3-030-14264-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis.  

Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.

The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Cholesterol-Recognition Motifs in Membrane Proteins

    Fantini, Jacques (et al.)

    Pages 3-25

  • Crystallographic Studies of Steroid-Protein Interactions

    Monzingo, Arthur F.

    Pages 27-45

  • Molecular Determinants of Cholesterol Binding to Soluble and Transmembrane Protein Domains

    Ounjian, Jessica (et al.)

    Pages 47-66

  • Modes of Cholesterol Binding in Membrane Proteins: A Joint Analysis of 73 Crystal Structures

    Wang, Cong (et al.)

    Pages 67-86

  • Effects of Cholesterol on GPCR Function: Insights from Computational and Experimental Studies

    Kiriakidi, Sofia (et al.)

    Pages 89-103

Buy this book

eBook $129.00
price for Mexico (gross)
  • ISBN 978-3-030-14265-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for Mexico
  • ISBN 978-3-030-14264-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Direct Mechanisms in Cholesterol Modulation of Protein Function
Editors
  • Avia Rosenhouse-Dantsker
  • Anna N. Bukiya
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1135
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-14265-0
DOI
10.1007/978-3-030-14265-0
Hardcover ISBN
978-3-030-14264-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 168
Number of Illustrations
1 b/w illustrations, 50 illustrations in colour
Topics