Breast Cancer Metastasis and Drug Resistance

1. Front Matter

   Pages i-xi

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2. Breast Cancer Statistics

   • Jiemin Ma, Ahmedin Jemal

   Pages 1-18

3. Epidemiology of Breast Cancer in Women

   • Steven S. Coughlin, Yasmin Cypel

   Pages 19-34

4. The Complexities of Racial Disparity in Breast Cancer

   • Joy Tang, Aamir Ahmad, Fazlul H. Sarkar

   Pages 35-46

5. Major Signaling Pathways Involved in Breast Cancer

   • Saba Wasim Aziz, Moammir Hasan Aziz

   Pages 47-64

6. Breast Cancer Heterogeneity in Primary and Metastatic Disease

   • Jodi M. Saunus, Amy McCart-Reed, Majid Momeny, Margaret Cummings, Sunil R. Lakhani

   Pages 65-95

7. Understanding Triple-Negative Breast Cancer

   • Ayca Gucalp, Tiffany A. Traina

   Pages 97-116

8. The Biology of the Deadly Love Connection Between Obesity, Diabetes, and Breast Cancer

   • Bin Bao, Anthony Oraha, Aamir Ahmad, Shadan Ali, Yiwei Li, Asfar S. Azmi et al.

   Pages 117-142

9. Progression of Early Breast Cancer to an Invasive Phenotype

   • Connor D. MacMillan, Ann F. Chambers, Alan B. Tuck

   Pages 143-159

10. Pre-Clinical Modeling of Breast Cancer: Which Model to Choose?

    • Claire Nash, Valerie Speirs

    Pages 161-175

11. Modeling Breast Cancer Progression in 4-D

    • Mansoureh Sameni, Stefanie R. Mullins, Kamiar Moin, Bonnie F. Sloane, Kingsley Osuala

    Pages 177-188

12. Bone Metastasis of Breast Cancer

    • Takae M. Brewer, Richard L. Theriault, Naoto T. Ueno

    Pages 189-209

13. Cellular and Molecular Mechanisms Involved in Breaching of the Blood–Brian Barrier by Circulating Breast Cancer Cells

    • Hava Karsenty Avraham, Shuxian Jiang, Lili Wang, Yigong Fu, Shalom Avraham

    Pages 211-226

14. Resistance to Anthracyclines and Taxanes in Breast Cancer

    • Derek Edwardson, Simon Chewchuk, Amadeo M. Parissenti

    Pages 227-247

15. Understanding Tamoxifen Resistance of Breast Cancer Based on Integrative Bioinformatics Approaches

    • Y. Dai, L. Huang

    Pages 249-260

16. Current Understanding of Drug Resistance Mechanisms and Therapeutic Targets in HER2 Overexpressing Breast Cancers

    • Aamir Ahmad, Fazlul H Sarkar

    Pages 261-274

17. Platinum and Ruthenium Complexes for the Therapy of Breast Cancer Diseases

    • Bernhard Biersack, Rainer Schobert

    Pages 275-290

18. Development of Notch Pathway Inhibitors for Cancer Therapy

    • Ingrid Espinoza, Lucio Miele

    Pages 291-327

19. Systems Biology Approaches in Breast Cancer Studies

    • Zhiwei Wang, Shavali Shaik, Hiroyuki Inuzuka, Wenyi Wei

    Pages 329-340

20. Epigenetic Factors in Breast Cancer Progression

    • Samriddhi Shukla, Syed Musthapa Meeran

    Pages 341-365

​This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to a) fully understand the disease with all its heterogeneity, b) understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and c) understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity/metastasis/drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed.  ​

• bone metastasis
• breast cancer statistics
• breast cancer stem cells
• tamoxifen
• triple negative breast cancer
• antibacterial drug resistance

• School of Medicine, Karmanos Cancer Institute, Wayne State University, Detroit, USA

  Aamir Ahmad

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