- Authored by international experts
- Provides a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development
- Describes cutting edge field
Buy this book
- About this book
-
A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.
- About the authors
-
Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.
- Table of contents (16 chapters)
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Introduction to the Microdialysis Technology
Pages 3-12
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Recovery and Calibration Techniques: Toward Quantitative Microdialysis
Pages 13-33
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Analytical Considerations for Microdialysis Sampling
Pages 35-66
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Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective
Pages 67-80
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Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations
Pages 83-102
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Table of contents (16 chapters)
- Download Preface 1 PDF (47.1 KB)
- Download Sample pages 2 PDF (574.2 KB)
- Download Table of contents PDF (63.7 KB)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Microdialysis in Drug Development
- Editors
-
- Markus Müller
- Series Title
- AAPS Advances in the Pharmaceutical Sciences Series
- Series Volume
- 4
- Copyright
- 2013
- Publisher
- Springer-Verlag New York
- Copyright Holder
- American Association of Pharmaceutical Scientists
- eBook ISBN
- 978-1-4614-4815-0
- DOI
- 10.1007/978-1-4614-4815-0
- Hardcover ISBN
- 978-1-4614-4814-3
- Softcover ISBN
- 978-1-4899-9621-3
- Series ISSN
- 2210-7371
- Edition Number
- 1
- Number of Pages
- XII, 340
- Topics
