Animal Models in Radiotracer Design

1. Front Matter

   Pages i-xiv

   PDF

2. Animal Models in Biomedical Research and Radiotracer Design

   • Richard M. Lambrecht, William C. Eckelman, Aldo Rescigno

   Pages 1-34

3. The Development of Radiotracers that Are Substrates for (Catecholamine) Uptake1 and Uptake2

   • Edward A. Carr Jr.

   Pages 35-59

4. Monoclonal Antibodies: The Design of Appropriate Carrier and Evaluation Systems

   • Brian M. Gallagher

   Pages 61-105

5. Small Animal Oncological Models for Screening Diagnostic Radiotracers

   • Leonard I. Wiebe

   Pages 107-147

6. 111In-Labeled Platelets for the Detection of Vascular Disorders in Animal Models

   • Carla J. Mathias, Michael J. Welch

   Pages 149-177

7. Animal Models in the Study of Hepatobiliary Radiotracers

   • Alan R. Fritzberg, Duane C. Bloedow

   Pages 179-209

8. Experimental Models and Evaluation of Animal Data for Renal Radiodiagnostic Agents

   • John G. McAfee, Gopal Subramanian

   Pages 211-227

9. Back Matter

   Pages 229-234

   PDF

The editors have asked me to write this foreword probably for two reasons: First, I have spent 35 years trying to develop radiolabeled compounds that would help diagnose and treat disease. I, and the people from my laboratory, have been much involved with developing Nan'I for the diagnosis and treatment of hyperthyroidism and well-differentiated thyroid cancer. Second, I was a participant throughout the entire symposium upon which this book is based. Our latest '311-labeled compound, [l3lll metaiodobenzylguanidine, took us 13 years to develop. It has succeeded in diagnosing and treating adrenergic tumors '31 under circumstances where Na 1 would have failed for the diagnosis and treatment of thyroid cancer. I therefore hope that more scientists will be attracted to this field. This book is written by intelligent, experienced investigators who are knowl­ edgeable. It is a must for anyone new in the field. For the experienced, I would like to remind you that I attended the entire symposium; the breadth and timeliness of the update has helped us to redirect some of our current efforts into more scientifically productive channels. William H. Beierwaltes, M.D.

• Design
• Tierversuch
• Tracer-Methode
• cancer
• diagnosis
• evaluation
• receptor
• tracer
• tumors

• Chemistry Department, Brookhaven National Laboratory, Upton, USA

  Richard M. Lambrecht

• Section of Radiopharmaceutical Chemistry, George Washington University Medical Center, USA

  William C. Eckelman

Policies and ethics