Overview
Completed and ongoing genome sequencing projects
Databases that store and organize genomic data, with their unique advantages and pitfalls
Principles and methods of genome analysis and annotation
Ways to automate the searches and increase search sensitivity while minimizing the error rate
The first lessons from the Human Genome Project
The contribution of comparative genomics to the understanding of hereditary diseases and cancer
Fundamental and practical applications of comparative genomics
Use of complete genomes for evolutionary analysis
Application of comparative genomics for identification of potential drug targets in microbial genomes
Problems for Further Study, which are designed to be solved by using methods available through the WWW
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis.
Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Authors and Affiliations
Bibliographic Information
Book Title: Sequence — Evolution — Function
Book Subtitle: Computational Approaches in Comparative Genomics
Authors: Eugene V. Koonin, Michael Y. Galperin
DOI: https://doi.org/10.1007/978-1-4757-3783-7
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media Dordrecht 2003
Hardcover ISBN: 978-1-4020-7274-1Published: 30 November 2002
Softcover ISBN: 978-1-4419-5321-6Published: 01 December 2010
eBook ISBN: 978-1-4757-3783-7Published: 29 June 2013
Edition Number: 1
Number of Pages: XIV, 462
Topics: Animal Anatomy / Morphology / Histology, Biochemistry, general, Microbiology, Evolutionary Biology, Human Genetics