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Exploring Pancreatic Metabolism and Malignancy

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  • © 2019

Overview

Editors:
  1. Ganji Purnachandra Nagaraju

    1. Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, USA

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  2. Aramati BM Reddy

    1. Department of Animal Biology, University of Hyderabad, Hyderabad, India

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  • Highlights different metabolic diseases that are involved in the etiology and progression of pancreatic cancer

  • Describes the roles of inflammatory pathways in pancreatic cancer cell growth and metastasis, including migration, invasion and angiogenesis

  • Elucidates the rational targets for diabetes and pancreatic cancer therapy

  • Reviews the advances in the treatment of pancreatic cancer using immunotherapy and anti-diabetic drugs

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xii
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  2. Biology of Pancreas and Possible Diseases

    • Gowru Srivani, Begum Dariya, Batoul Farran, Afroz Alam, Ganji Purnachandra Nagaraju
    Pages 1-25

  3. Pancreatitis: Clinical Aspects of Inflammatory Phenotypes

    • Nyshadham S. N. Chaitanya, Aramati BM Reddy
    Pages 27-33

  4. Diabetes and Pancreatic Cancer: A Bidirectional Relationship Perspective

    • Manoj Kumar Gupta, Vemula Sarojamma, Ramakrishna Vadde
    Pages 35-51

  5. Metabolic Adaptations in Diabetes Mellitus and Cancer

    • Anil Kumar Pasupulati, Nageswara Rao Dunna, Srikanth Talluri
    Pages 53-69

  6. Role of Mitochondria in Pancreatic Metabolism, Diabetes, and Cancer

    • Noble Kumar Talari, Ushodaya Mattam, Naresh Babu V. Sepuri
    Pages 71-94

  7. Targeting Mitochondrial Enzymes in Pancreatic Cancer

    • Gowru Srivani, Begum Dariya, Afroz Alam, Ganji Purnachandra Nagaraju
    Pages 95-110

  8. Diabetes with Pancreatic Ductal Adenocarcinoma

    • Gowru Srivani, Begum Dariya, Afroz Alam, Ganji Purnachandra Nagaraju
    Pages 111-131

  9. Role of Inflammatory Cytokines in the Initiation and Progression of Pancreatic Cancer

    • Madanraj Appiya Santharam, Vignesh Dhandapani
    Pages 133-156

  10. Perspectives and Molecular Understanding of Pancreatic Cancer Stem Cells

    • L. Saikrishna, Prameswari Kasa, Saimila Momin, L. V. K. S. Bhaskar
    Pages 157-172

  11. The Role of Hypoxia Inducible Factor-1α in Pancreatic Cancer and Diabetes Mellitus

    • Saimila Momin, Ganji Purnachandra Nagaraju
    Pages 173-181

  12. Role of Heat Shock Protein 90 in Diabetes and Pancreatic Cancer Management

    • Pinninti Santosh Sushma, Saimila Momin, Gowru Srivani
    Pages 183-195

  13. Insulin Resistance Is a Common Core Tethered to Diabetes and Pancreatic Cancer Risk

    • Henu Kumar Verma, L. V. K. S. Bhaskar
    Pages 197-213

  14. Immunotherapy for Diabetogenic Pancreatitis and Pancreatic Cancer: An Update

    • Sathish Kumar Mungamuri, Anil Kumar Pasupulati, Vijay Aditya Mavuduru
    Pages 215-236

  15. Exosomes: Mediators and Therapeutic Targets of Diabetes and Pancreatic Cancer

    • Deepak KGK, Rama Rao Malla
    Pages 237-251

  16. Methods and Models in Exploring Pancreatic Functions

    • Rama Rao Malla, Seema Kumari, Krishna Chaitanya Amajala, Deepak KGK, Shailender Gugalavath, Prasuja Rokkam
    Pages 253-268
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Keywords

About this book

This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers.

The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy.

Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.

Editors and Affiliations

  • Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, USA

    Ganji Purnachandra Nagaraju

  • Department of Animal Biology, University of Hyderabad, Hyderabad, India

    Aramati BM Reddy

About the editors

Dr. Nagaraju GP is a faculty member at the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Nagaraju obtained his M.Sc and Ph.D., both in biotechnology from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. Dr. Nagaraju received his D.Sc. from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju’s research focuses on translational research in gastrointestinal malignancies. He has published over 70 research papers in highly respected international journals and has presented more than 50 abstracts at various national and international conferences. He is author and editor of several. Dr. Nagaraju is an editorial board member of several internationally recognized academic journals, and is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He is a member of the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, The RNA Society and the American Association of Cancer Research (AACR).
Dr. Aramati BM Reddy is an Assistant Professor at the School of Life Sciences, University of Hyderabad, India. He obtained his Master’s in Biotechnology from SV University, Tirupati-India and Ph.D. from L.V. Prasad Eye Institute, University of Hyderabad, India. He received postdoctoral training at the University of Pennsylvania and University of Texas Medical Branch-Galveston-TX in epigenetics, inflammation, and metabolic disorders. Dr. Reddy’s lab research interests focus on understanding cell signaling and gene regulation in the pathophysiology of metabolic malignancies and glaucoma. His lab is also working on understanding the role of several candidate genes and their significance for the outflow pathway of the aqueous humor of the anterior segment of the eye and glaucoma pathology. He has published 30 research papers in peer-reviewed journals and four book chapters. In addition, he has co-edited three special issues for Hindawi publishers in the field of translational and health sciences. He is a life member for several societies and is currently an executive board member of the Indian society of cell biology. 

Bibliographic Information

  • Book Title: Exploring Pancreatic Metabolism and Malignancy

  • Editors: Ganji Purnachandra Nagaraju, Aramati BM Reddy

  • DOI: https://doi.org/10.1007/978-981-32-9393-9

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-32-9392-2Published: 19 December 2019

  • Softcover ISBN: 978-981-32-9395-3Published: 10 December 2020

  • eBook ISBN: 978-981-32-9393-9Published: 23 November 2019

  • Edition Number: 1

  • Number of Pages: XII, 268

  • Number of Illustrations: 6 b/w illustrations, 29 illustrations in colour

  • Topics: Cancer Research, Metabolic Diseases, Human Physiology, Diabetes, Immunology

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