Overview
- Presents expert opinions and up-to-date studies on tau
- Provides new insights into the tau molecule and tauopathies
- Offers inspiration for development of effective therapies
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1184)
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Table of contents (30 chapters)
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Front Matter
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Structure and Role of the Tau Molecule
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Front Matter
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Tau Localization and Function
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Front Matter
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Tau and Disease-Related Proteins
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Front Matter
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Keywords
About this book
This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
Editors and Affiliations
About the editors
Akihiko Takashima
Gakushuin University, Dept Life Sci., Lab Alzheimers Dis., Japan
Benjamin Wolozin
Boston University, School of Med., Dept Pharmacol., USA
Luc Buee
University of Lille, CHU Lille, INSERM, Memory & Resources Res. Ctr., France
Bibliographic Information
Book Title: Tau Biology
Editors: Akihiko Takashima, Benjamin Wolozin, Luc Buee
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-32-9358-8
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-32-9357-1Published: 25 February 2020
Softcover ISBN: 978-981-32-9360-1Published: 26 August 2021
eBook ISBN: 978-981-32-9358-8Published: 24 February 2020
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XI, 416
Number of Illustrations: 8 b/w illustrations, 75 illustrations in colour
Topics: Neurosciences, Human Physiology, Neurobiology, Neurology, Protein Science