Get 40% off of select print and eBooks in Engineering & Materials Science!

Springer Theses

SIRT6 Activities in DNA Damage Repair and Premature Aging

Functions of SIRT6

Authors: Ghosh, Shrestha

Free Preview
  • Nominated as an outstanding PhD thesis in the field by the University of Hong Kong 
  • Illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging
  • Presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation, etc
see more benefits

Buy this book

eBook n/a
  • ISBN 978-981-329-267-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-981-329-266-6
  • Free shipping for individuals worldwide
About this book

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.

About the authors

Dr Shrestha Ghosh is currently a Postdoctoral Research Fellow at Dana Farber Cancer Institute, Harvard Medical School, USA. She earned her Bachelor’s Degree from the National Institute of Technology, Durgapur, India as a Gold medalist in 2011. She then moved to Hong Kong to pursue her PhD.

She began her work at the School of Biomedical Sciences, University of Hong Kong, as a research assistant to Prof. Zhongjun Zhou, who would later become her PhD advisor. Dr Ghosh completed her PhD in 2017. During her doctoral studies, she primarily focused on premature aging and DNA damage responses. 

From 2012 to 2017, she contributed to one book chapter and seven research articles, including two as first author. During this period, she also mentored several summer interns and a final-year Bachelor student. She won the first runner-up and people’s choice award at a 3-minute Thesis competition hosted by the University of Hong Kong in 2017, and later represented HKU at the Asia Pacific 3-minute Thesis competition held at the University of Queensland, Australia. In the last year of her research in HKU, she received several accolades, including the Reaching Out Excellence award bestowed by the HKSAR government

Table of contents (6 chapters)

Table of contents (6 chapters)
  • Introduction

    Pages 1-59

    Ghosh, Dr. Shrestha

  • Materials and Methods

    Pages 61-72

    Ghosh, Dr. Shrestha

  • Results-I. Lamin A is an Endogenous Activator of SIRT6 in DNA Damage Repair Process

    Pages 73-95

    Ghosh, Dr. Shrestha

  • Results-II. Haploinsufficiency of p53 Rescues Lifespan and Premature Aging-Associated Abnormalities in Sirt6-Deficient Mice

    Pages 97-126

    Ghosh, Dr. Shrestha

  • Results-III. SIRT6 Is an Acetylated Protein and a NAD+-Dependent Self-deacetylase

    Pages 127-137

    Ghosh, Dr. Shrestha

Buy this book

eBook n/a
  • ISBN 978-981-329-267-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-981-329-266-6
  • Free shipping for individuals worldwide
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
SIRT6 Activities in DNA Damage Repair and Premature Aging
Book Subtitle
Functions of SIRT6
Authors
Series Title
Springer Theses
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-329-267-3
DOI
10.1007/978-981-32-9267-3
Hardcover ISBN
978-981-329-266-6
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XLV, 151
Topics