Skip to main content
SpringerLink
Log in
Book cover

Therapeutic Enzymes: Function and Clinical Implications

  • Book
  • © 2019

Overview

Editors:
  1. Nikolaos Labrou

    1. Department of Biotechnology, Agricultural University of Athens, Athens, Greece

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Incorporates a wealth of research that clarifies several aspects of the development and application of therapeutic enzymes
  • Equips readers with a comprehensive understanding of enzyme-based therapeutic molecules
  • Emphasizes three areas of recombinant therapeutic enzymes and their clinical and pharmaceutical technology

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1148)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Production and Purification of Therapeutic Enzymes

    • M. Ângela Taipa, Pedro Fernandes, Carla C. C. R. de Carvalho
    Pages 1-24

  3. Production of Therapeutic Enzymes by Lentivirus Transgenesis

    • María Celeste Rodríguez, Natalia Ceaglio, Sebastián Antuña, María Belén Tardivo, Marina Etcheverrigaray, Claudio Prieto
    Pages 25-54

  4. Quality Control and Downstream Processing of Therapeutic Enzymes

    • David Gervais
    Pages 55-80

  5. X-Ray Crystallography in Structure-Function Characterization of Therapeutic Enzymes

    • Anastassios C. Papageorgiou
    Pages 81-103

  6. Application of Fluorescence in Studying Therapeutic Enzymes

    • Zhaoshuai Wang, Caihong Li, Yinan Wei
    Pages 105-114

  7. Key Physicochemical Characteristics Influencing ADME Properties of Therapeutic Proteins

    • Xing Jing, Yan Hou, William Hallett, Chandrahas G. Sahajwalla, Ping Ji
    Pages 115-129

  8. Stability of Therapeutic Enzymes: Challenges and Recent Advances

    • Shubhrima Ghosh, Shahenvaz Alam, Anurag S. Rathore, S. K. Khare
    Pages 131-150

  9. Engineering Strategies for Oral Therapeutic Enzymes to Enhance Their Stability and Activity

    • Philipp Lapuhs, Gregor Fuhrmann
    Pages 151-172

  10. Enzymes in Metabolic Anticancer Therapy

    • Maristella Maggi, Claudia Scotti
    Pages 173-199

  11. Alkaline Phosphatase Replacement Therapy

    • Maria Luisa Bianchi, Silvia Vai
    Pages 201-232

  12. Enzybiotics: Enzyme-Based Antibacterials as Therapeutics

    • Dorien Dams, Yves Briers
    Pages 233-253

  13. Clinical Applications of Hyaluronidase

    • Gregor Cornelius Weber, Bettina Alexandra Buhren, Holger Schrumpf, Johannes Wohlrab, Peter Arne Gerber
    Pages 255-277

  14. Alkaline Phosphatase Replacement Therapy for Hypophosphatasia in Development and Practice

    • S. A. Bowden, B. L. Foster
    Pages 279-322

  15. Rational Use of Pancreatic Enzymes for Pancreatic Insufficiency and Pancreatic Pain

    • Gyanprakash A. Ketwaroo, David Y. Graham
    Pages 323-343

  16. Fibrinolytic Enzymes for Thrombolytic Therapy

    • Swaroop S. Kumar, Abdulhameed Sabu
    Pages 345-381

  17. Back Matter

    Pages 383-386
    Download chapter PDF
Back to top

Keywords

About this book

Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.

Editors and Affiliations

  • Department of Biotechnology, Agricultural University of Athens, Athens, Greece

    Nikolaos Labrou

Bibliographic Information

  • Book Title: Therapeutic Enzymes: Function and Clinical Implications

  • Editors: Nikolaos Labrou

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-13-7709-9

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-13-7708-2Published: 23 September 2019

  • Softcover ISBN: 978-981-13-7711-2Published: 23 September 2020

  • eBook ISBN: 978-981-13-7709-9Published: 03 September 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 386

  • Number of Illustrations: 19 b/w illustrations, 71 illustrations in colour

  • Topics: Protein Science

Publish with us

Policies and ethics

Back to top

Search

Navigation