Tumor Angiogenesis

1. Front Matter

   Pages i-xxii

   PDF

2. Mechanisms of Tumor Angiogenesis

   1. Front Matter

      Pages 1-1

      PDF

   2. Mechanisms of Tumor Angiogenesis

      • Iratxe Zuazo-Gaztelu, Oriol Casanovas

      Pages 3-31

   3. The Role of VEGF in Controlling Vascular Permeability

      • Lakshmi Venkatraman, Lena Claesson-Welsh

      Pages 33-50

   4. Benefits and Pitfalls of Tumor Vessel Normalization

      • Jin-Sung Park, Intae Park, Gou Young Koh

      Pages 51-71

   5. The Impact of Endothelial Transcription Factors in Sprouting Angiogenesis

      • Melanie Hofmann, Joerg Heineke

      Pages 73-90

   6. Endothelial Cell-Cell Junctions in Tumor Angiogenesis

      • Quentin Roux, Julie Gavard

      Pages 91-119

   7. Controlling Vascular Permeability: How Does It Work and What Is the Impact on Normal and Pathological Angiogenesis

      • Inga Bekes, Christine Wulff

      Pages 121-132

3. Mechanisms of Tumor Lymphangiogenesis

   1. Front Matter

      Pages 133-133

      PDF

   2. Angiopoietins and TIE Receptors in Lymphangiogenesis and Tumor Metastasis

      • Yulong He

      Pages 135-156

   3. Significance and Molecular Regulation of Lymphangiogenesis in Cancer

      • Mihaela Skobe, Bronislaw Pytowski

      Pages 157-179

4. Mechanisms of Anti-angiogenic Therapy

   1. Front Matter

      Pages 181-181

      PDF

   2. Mechanisms of Anti-angiogenic Therapy

      • Roser Pons-Cursach, Oriol Casanovas

      Pages 183-208

5. Anti-angiogenic Targets

   1. Front Matter

      Pages 209-209

      PDF

   2. The Role of the VEGF Signaling Pathway in Tumor Angiogenesis

      • Napoleone Ferrara

      Pages 211-226

   3. Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors

      • Elina A. Kiss, Pipsa Saharinen

      Pages 227-250

6. Pathology of Tumor Angiogenesis

   1. Front Matter

      Pages 251-251

      PDF

   2. Pathology of Tumor Angiogenesis

      • Peter Bronsert, Martin Werner

      Pages 253-274

7. Imaging of Tumor Angiogenesis

   1. Front Matter

      Pages 275-275

      PDF

   2. Imaging Tumor Angiogenesis

      • Gordon Jayson, James O’Connor

      Pages 277-290

This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.​

• Biomarkers
• Oncology
• Personalised Tumor Therapy
• Targeted Tumor Therapy
• Tumor-Angiogenesis

• Tumor Biology Center, Freiburg, Germany

  Dieter Marmé

Dieter Marmé is renowned for his scientific work on molecular biology and tumor biology, and in particular for research into the roles of growth factors in the mechanisms by which tumor angiogenesis is initiated and propagated. At the time of his retirement in 2005, he had spent more than two decades at the Tumor Biology Center in Freiburg, Germany. He initially joined the Center as Director of the Institute of Molecular Medicine in 1993 and later served as its Director of Research and Chairman of the Board of Directors. Prior to joining the Tumor Biology Center, Dr. Marmé had been an Extraordinary Professor in the Department of Genetics and Molecular Biology at the University of Freiburg and had then spent a decade working for Gödecke, a division of Parke-Davis (now Pfizer), initially as Head of Pharmacological Biochemistry and later as Head of Biological Research. Based on the understanding of the mechanisms by which tumors progress and tumor angiogenesis is initiated, he focused on the investigation of therapeutic concepts to interfere with the development of malignancies. After retiring from the Tumor Biology Center in 2005, he continued to work for the institution as an Adviser in Oncology and at the same time became a member of the editorial board for various journals in the field of oncology and a consultant for pharmaceutical companies. Dr. Marmé is the coeditor of the previous Springer book Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy (2008).

Policies and ethics