Editors:
- Introduces assays for thiols and modification as well as pitfalls of ROS measurements by fluorescent probes
- Describes methods and reagents as well as instrumental methods for measuring oxidants and oxidative stress in biological systems
- Provides clinically related models and approaches
Part of the book series: Biological Magnetic Resonance (BIMR, volume 34)
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Table of contents (11 chapters)
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Front Matter
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Clinically Related Models and Approaches
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Front Matter
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Back Matter
About this book
This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Editors and Affiliations
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Department of Chemistry and Biochemistry, University of Denver, Centennial, USA
Lawrence J. Berliner
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Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Ohio State University College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, Columbus, USA
Narasimham L. Parinandi
About the editors
He spends a great deal of his time mentoring young scientists on career decisions and aspirations. For those who know him personally, he is someone who sees the world in a bigger perspective. While he had more than once concluded that spin labelling had run its course and had reached a dead-end, yet he admits that spin labelling continues to flourish and has probably met a renaissance in the 2000s with site directed spin labelling approaches and the many new techniques that colleagues in high field EPR have developed. He summarized his perspective of the History of Spin Labelling and In-Vivo EPR in a festschrift issue of the European Biophysics Journal (2010) and Biomedical Spectroscopy and Imaging (2016).
Narasimham L. Parinandi (pAri) is an Associate Professor in Department of Internal Medicine, The Ohio State University College of Medicine. Parinandi received his B.Sc. (Hons) in botany with chemistry, zoology, English and M.Sc. in Botany with Environmental Biology in Berhampur University, India in 1975-77. From 1977-80, he was a research fellow in Environmental Sciences at the Andhra University, India. He earned his Ph.D. (1986) at the University of Toledo, Toledo, OH in Biology & Toxicology under the tutelage of Prof. Woon H. Jyung, an established zinc metabolism expert and aging biologist. During his graduate training at Toledo, he was exposed to the field of lipids by Prof. Max Funk, an expert lipoxygenase enzymologist from the lineage of Prof. Ned Porter. He did his post-doctoral fellowship (1986-90) at the Hormel Institute, University of Minnesota, the premier lipid institute in USA where he was trained with Prof. Harald Schmid, a celebrity in the area of ether lipids and a pioneer in anandamide chemistry. At the Hormel Institute of the University of Minnesota, Parinandi was associated with Prof. Ralph T. Holman (Member of the National Academy of Sciences and Pioneer in Fatty Acid and Lipoxygenase Biochemistry who also coined the name “Omega-3 Fatty Acid”) and conducted studies on omega-3 fatty acid dynamics in humans (the Keralites with Prof. T. Rama Sarma of the Indian Institute of Sciences). Parinandi also was an editor at the American Chemical Society’s Chemical Abstracts Service in the Department of Biochemistry. He was also a research scientist/junior faculty at the Johns Hopkins University School of Medicine (1998-2002) under the mentorship of Prof. V. Natarajan, renowned lipid signalling expert and Prof. Joe G.N. (Skip) Garcia, a celebrated lung vascular biologist. Since his tenure at the Johns Hopkins University School of Medicine, Parinandi has been trained in Oxygen Biochemistry and Analysis and Electron Paramagnetic Resonance (EPR) Spectroscopy by Prof. Periannan Kuppusamy, a celebrity in EPR Imaging and Oxygen bioanalysis and ever since both have been working together on oxygen and radical biology. Parinandi has published nearly 125 peer-reviewed original scientific papers, reviews, and book chapters, and edited books on Free Radicals and Antioxidant Protocols with Prof. William Pryor, the legendary Free Radical and Lipid Peroxidation Scientist and Mitochondria in Lung Health and Disease with Prof. Natarajan, a lipid signalling celebrity. Parinandi collaborated and published original research papers with the Nobel Laureate, Prof. Louis Ignarro on the pharmacology of NO donor drug. Currently, Parinandi is editing a Springer book on the Methods of Determination of Oxidative Stress with Prof. Lawrence Berliner of Denver University, a legendary scientist of Biological EPR Spectroscopy and Imaging. Parinandi has given more than 50 invited scientific lectures at the national level in the US and international institutions and conferences. He has also conducted and chaired several scientific conferences and symposia in the areas of oxidative stress and lipidology. He has teaching and mentoring experience of more than 35 years and mentored over 75 students, technicians, fellows, and junior faculty in his laboratory. He served as an editor of Toxicology and Biochemistry sections of the Chemical Abstracts of the American Chemical Society from 1990-98. He has been a reviewer of nearly 70 peer-reviewed journals in the area of biochemistry, molecular biology, cell biology and Lipidomics. Parinandi has been on the editorial board of the Molecular Biology Reports (Springer), Frontiers of Pharmacology (Review Editor for Translational Pharmacology), World Journal of GI Pharmacology, Vessel Plus, Cell Biophysics and Biochemistry (Associate Editor), and The Protein Journal. He has also received extramural funding from the National Institutes of Health (NIH), Department of Defense (DOD), American Thoracic Society (ATS), and International Academy of Oral Medicine and Toxicology (IAOMT) as a principal investigator (PI) and co-investigator (Co-I). Parinandi also serves as a reviewer of grant proposals of the NIH, AHA, DOD, US Universities, Government of Israel, Government of Austria, and Government of South Africa. Parinandi has received awards including the Gold Medal for securing the highest GPA in the M.S. class of 1975-77 of the Berhampur University, India, the Outstanding Teaching Assistant Award ofthe Biology Department of the University of Toledo in 1986, Distinguished Mentor Award of the Davis Heart & Lung Research Institute of the Ohio State University College of Medicine and the Wexner Medical Center in 2008, and the Distinguished Undergraduate Mentor Award of the Ohio State Undergraduate Research Program in 2009.
Bibliographic Information
Book Title: Measuring Oxidants and Oxidative Stress in Biological Systems
Editors: Lawrence J. Berliner, Narasimham L. Parinandi
Series Title: Biological Magnetic Resonance
DOI: https://doi.org/10.1007/978-3-030-47318-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-47317-4Published: 09 August 2020
Softcover ISBN: 978-3-030-47320-4Published: 10 August 2021
eBook ISBN: 978-3-030-47318-1Published: 08 August 2020
Series ISSN: 0192-6020
Series E-ISSN: 2512-2215
Edition Number: 1
Number of Pages: XIV, 237
Number of Illustrations: 48 b/w illustrations, 37 illustrations in colour
Topics: Oxidative Stress, Systems Biology, Cell Cycle Analysis