Bacterial Membrane Vesicles

1. Front Matter

   Pages i-xii

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2. Introduction, History, and Discovery of Bacterial Membrane Vesicles

   • Lauren Zavan, Natalie J. Bitto, Maria Kaparakis-Liaskos

   Pages 1-21

3. Biogenesis of Gram-Negative OMVs

   • Franz G. Zingl, Deborah R. Leitner, Stefan Schild

   Pages 23-46

4. Biogenesis and Function of Extracellular Vesicles in Gram-Positive Bacteria, Mycobacteria, and Fungi

   • Ainhoa Palacios, Carolina Coelho, Maria Maryam, Jose L. Luque-García, Arturo Casadevall, Rafael Prados-Rosales

   Pages 47-74

5. Extracellular Vesicles in the Environment

   • Steven J. Biller

   Pages 75-99

6. Functions of MVs in Inter-Bacterial Communication

   • Masanori Toyofuku, Yosuke Tashiro, Nobuhiko Nomura, Leo Eberl

   Pages 101-117

7. Membrane Vesicles from Plant Pathogenic Bacteria and Their Roles During Plant–Pathogen Interactions

   • Ofir Bahar

   Pages 119-129

8. Delivery of Virulence Factors by Bacterial Membrane Vesicles to Mammalian Host Cells

   • Aftab Nadeem, Jan Oscarsson, Sun Nyunt Wai

   Pages 131-158

9. Immunodetection and Pathogenesis Mediated by Bacterial Membrane Vesicles

   • Ella L. Johnston, Thomas A. Kufer, Maria Kaparakis-Liaskos

   Pages 159-188

10. Membrane Vesicles from the Gut Microbiota and Their Interactions with the Host

    • Josefa Badia, Laura Baldomà

    Pages 189-217

11. Bacterial Membrane Vesicles and Their Applications as Vaccines and in Biotechnology

    • Julie C. Caruana, Scott A. Walper

    Pages 219-251

This book focuses on the multitude of functions bacterial membrane vesicles perform in bacterial ecology and pathogenesis as well as in emerging medical and biotechnological applications. Both Gram-negative and Gram-positive bacteria produce membrane-bound nanostructures, known as membrane vesicles, which have a range of functions that include serving as delivery vehicles, providing a means of communication over both spatial and temporal scales, and contributing to bacterial survival and evolution. Topics covered in this book range from the biogenesis and composition of bacterial membrane vesicles to their abundance and biological roles in microbial ecosystems, such as marine environments. In the individual chapters, the involvement of bacterial membrane vesicles in host-pathogen interactions, promoting virulence and in facilitating the establishment of infection is explained. In addition, current knowledge regarding membrane vesicles produced by commensal bacteria and their role in the maturation of the host immune system, as well as the therapeutic potential of bacterial membrane vesicles as delivery systems and innovative nanotechnology-based therapeutics are discussed.

This work appeals to a wide readership of students and researchers interested in microbial ecology, mechanism underlying pathogenesis and new avenues in applied microbiology and nanotechnology.

• Outer Membrane Vesicles
• OMVs release internalization
• Gram-negative bacteria vesicles
• MVs virulence factors
• pathogenesis immune modulation
• extracellular milieu
• periplasmic content
• microbial interactions
• bacterial communities
• vaccine development
• membrane-bound material
• microvesicles, exosomes
• virus-like particles

• Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Australia

  Maria Kaparakis-Liaskos

• Department of Immunology, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany

  Thomas A. Kufer

Associate Professor Maria Kaparakis-Liaskos

Associate Professor Maria Kaparakis-Liaskos is Head of the Host-pathogen Interactions and Bacterial Membrane Vesicles Laboratory at La Trobe University, Australia. She is also the Deputy Director of the La Trobe Research Centre for Extracellular Vesicles. Her recent research activities focus on understanding the cellular and molecular mechanisms of host-pathogen interactions with particular focus on bacterial membrane vesicles.

Associate Professor Kaparakis-Liaskos obtained her PhD from the Department of Microbiology and Immunology at the University of Melbourne in Australia in 2005. She then undertook post-doctoral studies at Monash University, working on innate immune responses to Helicobacter pylori and bacterial outer membrane vesicles. She then headed a research group at the Hudson Institute of Medical Research, Australia during which time she identified the mechanisms whereby OMVs were detected by NOD1 and were degraded by autophagy. In 2016, she joined La Trobe University in Melbourne, Australia, where her research is supported by the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) and the Victorian Endowment for Science Knowledge and Innovation (veski).

 Professor Thomas A. Kufer

Professor Thomas Kufer is head of the Department of Immunology at the University of Hohenheim, Stuttgart, Germany. His primary research interests are focused on understanding the functions of NLR proteins in host-pathogen interactions, immunity and inflammation.

Professor Kufer obtained his PhD (Dr. rer. nat.) in Cell Biology from the Ludwig-Maximilians University of Munich in 2004. He then undertook post-doctoral studies in the laboratories of Dana Philpott and Philippe Sansonetti in the Pasteur Institute in Paris working on the intracellular pattern recognition receptors NOD1 and NOD2 in the context of Shigella flexneri infection. Subsequently he headed a junior research group funded by the German Research Foundation (DFG) at the Institute of Medical Microbiology, Immunology and Hygiene at University of Cologne in Germany working on innate immune responses mediated by NLR proteins. In 2014 he was recruited at the University of Hohenheim as professor for immunology.

 

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