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Prostate Cancer

Cellular and Genetic Mechanisms of Disease Development and Progression

  • Book
  • © 2019

Overview

Editors:
  1. Scott M. Dehm

    1. Department of Laboratory Medicine and Pathology, Department of Urology, Masonic Cancer Center, University of Minnesota, Minneapolis, USA

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  2. Donald J. Tindall

    1. Departments of Urology, and Biochemistry & Molecular Biology, Mayo Clinic College of Medicine, Rochester, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Offers a comprehensive scope ranging from disease initiation to metastasis
  • Focus and emphasis on genetic and cellular mechanisms of prostate cancer
  • Geared toward basic scientists, instead of largely clinically oriented

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1210)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Diet and Lifestyle in Prostate Cancer

    • Kathryn M. Wilson, Lorelei A. Mucci
    Pages 1-27

  3. Dietary Carcinogens and DNA Adducts in Prostate Cancer

    • Medjda Bellamri, Robert J. Turesky
    Pages 29-55

  4. Genetic, Environmental, and Nuclear Factors Governing Genomic Rearrangements

    • Susmita G. Ramanand, Ram S. Mani
    Pages 57-66

  5. Cells of Origin for Prostate Cancer

    • Li Xin
    Pages 67-86

  6. Prostate Cancer Genomic Subtypes

    • Michael Fraser, Alexandre Rouette
    Pages 87-110

  7. Prostate Cancer Transcriptomic Subtypes

    • Daniel E. Spratt
    Pages 111-120

  8. Immunological Complexity of the Prostate Cancer Microenvironment Influences the Response to Immunotherapy

    • Nataliya Prokhnevska, Dana A. Emerson, Haydn T. Kissick, William L. Redmond
    Pages 121-147

  9. The Tumor Microenvironments of Lethal Prostate Cancer

    • William L. Harryman, Noel A. Warfel, Raymond B. Nagle, Anne E. Cress
    Pages 149-170

  10. The Bone Microenvironment in Prostate Cancer Metastasis

    • Anthony DiNatale, Alessandro Fatatis
    Pages 171-184

  11. Prostate Cancer Energetics and Biosynthesis

    • Chenchu Lin, Travis C. Salzillo, David A. Bader, Sandi R. Wilkenfeld, Dominik Awad, Thomas L. Pulliam et al.
    Pages 185-237

  12. Canonical and Noncanonical Androgen Metabolism and Activity

    • Karl-Heinz Storbeck, Elahe A. Mostaghel
    Pages 239-277

  13. Germline and Somatic Defects in DNA Repair Pathways in Prostate Cancer

    • Sara Arce, Alejandro Athie, Colin C. Pritchard, Joaquin Mateo
    Pages 279-300

  14. The Role of RB in Prostate Cancer Progression

    • Deborah L. Burkhart, Katherine L. Morel, Anjali V. Sheahan, Zachary A. Richards, Leigh Ellis
    Pages 301-318

  15. Interplay Among PI3K/AKT, PTEN/FOXO and AR Signaling in Prostate Cancer

    • Yuqian Yan, Haojie Huang
    Pages 319-331

  16. Androgen Receptor Dependence

    • Aashi P. Chaturvedi, Scott M. Dehm
    Pages 333-350

  17. Wnt/Beta-Catenin Signaling and Prostate Cancer Therapy Resistance

    • Yunshin Yeh, Qiaozhi Guo, Zachary Connelly, Siyuan Cheng, Shu Yang, Nestor Prieto-Dominguez et al.
    Pages 351-378

  18. Epigenetic Regulation of Chromatin in Prostate Cancer

    • Ramakrishnan Natesan, Shweta Aras, Samuel Sander Effron, Irfan A. Asangani
    Pages 379-407

  19. Oncogenic ETS Factors in Prostate Cancer

    • Taylor R. Nicholas, Brady G. Strittmatter, Peter C. Hollenhorst
    Pages 409-436

  20. Neural Transcription Factors in Disease Progression

    • Daksh Thaper, Sepideh Vahid, Amina Zoubeidi
    Pages 437-462
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Keywords

About this book

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis.


Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

Editors and Affiliations

  • Department of Laboratory Medicine and Pathology, Department of Urology, Masonic Cancer Center, University of Minnesota, Minneapolis, USA

    Scott M. Dehm

  • Departments of Urology, and Biochemistry & Molecular Biology, Mayo Clinic College of Medicine, Rochester, USA

    Donald J. Tindall

About the editors

Scott Dehm is Professor in the Departments of Laboratory Medicine and Pathology and Urology at University of Minnesota.  He holds the Apogee Enterprises Chair of Cancer Research at the Masonic Cancer Center, University of Minnesota.  He obtained his Ph.D. degree in Biochemistry from the University of Saskatchewan.

Donald Tindall is Professor Emeritus in the Departments of Biochemistry and Molecular Biology and Urology at Mayo Clinic.  He obtained his Ph.D. degree from the University of North Carolina at Chapel Hill.

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