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Persister Cells and Infectious Disease

  • Book
  • © 2019

Overview

Editors:
  1. Kim Lewis

    1. Antimicrobial Discovery Center, Northeastern University, Boston, USA

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  • Provides an understanding of the mechanisms of persister formation
  • Gives an insight into the role of persisters in infectious disease
  • Discusses the aspects of persister formation in antibiotic resistence

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-x
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  2. Evolution Under Antibiotic Treatments: Interplay Between Antibiotic Persistence, Tolerance, and Resistance

    • Nathalie Q. Balaban, Jiafeng Liu
    Pages 1-17

  3. Antibiotic Persisters and Relapsing Salmonella enterica Infections

    • Peter W. S. Hill, Sophie Helaine
    Pages 19-38

  4. The Biology of Persister Cells in Escherichia coli

    • Alexander Harms
    Pages 39-57

  5. Persister Formation and Antibiotic Tolerance of Chronic Infections

    • Kim Lewis, Sylvie Manuse
    Pages 59-75

  6. Persister Formation Driven by TisB-Dependent Membrane Depolarization

    • Bork A. Berghoff, E. Gerhart H. Wagner
    Pages 77-97

  7. Nutrient Depletion and Bacterial Persistence

    • Wendy W. K. Mok, Mark P. Brynildsen
    Pages 99-132

  8. Genetic Determinants of Persistence in Escherichia coli

    • Dorien Wilmaerts, Pauline Herpels, Jan Michiels, Natalie Verstraeten
    Pages 133-180

  9. Toxin-Antitoxin Systems and Persistence

    • Nathan Fraikin, Frédéric Goormaghtigh, Laurence Van Melderen
    Pages 181-202

  10. Persister Resuscitation

    • Arvi Jõers, Marta PutrinÅ¡, Niilo Kaldalu, Hannes Luidalepp, Tanel Tenson
    Pages 203-216

  11. Host–Pathogen Interactions Influencing Mycobacterium tuberculosis Persistence and Drug Tolerance

    • Huiqing Zheng, Robert B. Abramovitch
    Pages 217-245

  12. Drug Susceptibility of Individual Mycobacterial Cells

    • Maikel Boot, E. Hesper Rego
    Pages 247-272

  13. Antimicrobial Drug Discovery Against Persisters

    • Wooseong Kim, Iliana Escobar, Beth Burgwyn Fuchs, Eleftherios Mylonakis
    Pages 273-295
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Keywords

About this book

This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level. 

Editors and Affiliations

  • Antimicrobial Discovery Center, Northeastern University, Boston, USA

    Kim Lewis

About the editor

Professor Kim Lewis, Northeastern University Boston, Massachusetts, USA

Bibliographic Information

  • Book Title: Persister Cells and Infectious Disease

  • Editors: Kim Lewis

  • DOI: https://doi.org/10.1007/978-3-030-25241-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-25240-3Published: 26 November 2019

  • Softcover ISBN: 978-3-030-25243-4Published: 26 November 2020

  • eBook ISBN: 978-3-030-25241-0Published: 13 November 2019

  • Edition Number: 1

  • Number of Pages: X, 295

  • Number of Illustrations: 6 b/w illustrations, 28 illustrations in colour

  • Topics: Medical Microbiology, Immunology, Infectious Diseases

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