Supramolecules in Drug Discovery and Drug Delivery

1. Front Matter

   Pages i-xi

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2. Application of Neutralization and Freeze-Drying Technique for the Preparation of the Beneficial in Drug Delivery 2-Hydroxypropyl-β-Cyclodextrin Complexes with Bioactive Molecules

   • Eirini Christodoulou, Dimitrios Ntountaniotis, Georgios Leonis, Thomas Mavromoustakos, Georgia Valsami

   Pages 1-11

3. Functionalized Carbon Nanohorns as Drug Delivery Platforms

   • Anastasios Stergiou, Nikos Tagmatarchis

   Pages 13-24

4. Ultrasonics-Assisted Effective Isolation and Characterization of Exosomes from Whole Organs

   • Burak Derkus, Emel Emregul

   Pages 25-34

5. Aggregate Determination by Permeation Technique

   • Phennapha Saokham, Thorsteinn Loftsson

   Pages 35-43

6. Study of Candesartan Cilexetil: 2-Hydroxypropyl-β-Cyclodextrin Interactions : A Computational Approach Using Steered Molecular Dynamics Simulations

   • Sofia Kiriakidi, Thomas Mavromoustakos

   Pages 45-70

7. Drug Delivery : Hydrophobic Drug  Encapsulation into Amphiphilic Block Copolymer  Micelles

   • Angeliki Chroni, Varvara Chrysostomou, Athanasios Skandalis, Stergios Pispas

   Pages 71-83

8. Multisensitive Polymeric Nanocontainers as Drug Delivery Systems: Biological Evaluation

   • Maria Theodosiou, Theodora Koutsikou, Eleni K. Efthimiadou

   Pages 85-97

9. Drug Incorporation in the Drug Delivery System of Micelles

   • Evangelia Soumelidou, Simona Golič Grdadolnik, Thomas Mavromoustakos

   Pages 99-108

10. Molecular Dynamics Protocols for the Study of Cyclodextrin Drug Delivery Systems

    • Georgios Leonis, Dimitrios Ntountaniotis, Eirini Christodoulou, Thomas Mavromoustakos

    Pages 109-125

11. Drug Delivery Through Multifunctional Polypeptidic Hydrogels

    • Hermis Iatrou, Panagiota G. Fragouli, Dimitra Stavroulaki, Barbara Athanasiou

    Pages 127-137

12. Polymersomes from Hybrids -Polypeptides for Drug Delivery Applications

    • Hermis Iatrou, Panagiota G. Fragouli, Dimitris Skourtis, Ioanna Stavropoulou

    Pages 139-150

13. Drug Delivery Systems Based on Modified Polysaccharides: Synthesis and Characterization

    • Aikaterini-Foteini Metaxa, Eleni Vrontaki, Eleni K. Efthimiadou, Thomas Mavromoustakos

    Pages 151-161

14. Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery Formulations

    • Nikolaos Naziris, Maria Chountoulesi, Dimitrios Ntountaniotis, Thomas Mavromoustakos, Costas Demetzos

    Pages 163-174

15. Encapsulation of Small Drugs in a Supramolecule Enhances Solubility , Stability, and Therapeutic Efficacy Against Glioblastoma Multiforme

    • Antonis D. Tsiailanis, Alexander Renziehausen, Serdar Karakurt, Tim Crook, Nelofer Syed, Andreas G. Tzakos

    Pages 175-186

16. Unveiling the Thermodynamic Aspects of Drug-Cyclodextrin Interactions Through Isothermal Titration Calorimetry

    • Maria V. Chatziathanasiadou, Thomas Mavromoustakos, Andreas G. Tzakos

    Pages 187-198

17. Antitumor Efficacy of Ceranib-2 with Nano-Formulation of PEG and Rosin Esters

    • Ali Ben Taleb, Selcan Karakuş, Ezgi Tan, Merve Ilgar, Özlem Kutlu, Devrim Gözüaçık et al.

    Pages 199-220

18. Association of the Thermodynamics with the Functionality of Thermoresponsive Chimeric Nanosystems

    • Nikolaos Naziris, Athanasios Skandalis, Thomas Mavromoustakos, Stergios Pispas, Costas Demetzos

    Pages 221-233

19. 2D DOSY NMR: A Valuable Tool to Confirm the Complexation in Drug Delivery Systems

    • Christos M. Chatzigiannis, Sofia Kiriakidi, Andreas G. Tzakos, Thomas Mavromoustakos

    Pages 235-246

20. Drug-Encapsulated Cyclodextrin Nanosponges

    • Maria Tannous, Fabrizio Caldera, Gjylije Hoti, Umberto Dianzani, Roberta Cavalli, Francesco Trotta

    Pages 247-283

This detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems. Beginning with a collection of chapters on drug delivery platforms such as cyclodextrins, micelles, liposomes, polymeric, nanotubes, and more, the volume continues with coverage of the study of nanotechnology systems using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and electrochemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols serves as an ideal guide for researchers working toward drug delivery mechanisms that can tailor their physical chemical properties and enhance their efficacy, while retaining their structures intact.

• Drug delivery platforms
• Drug delivery systems
• Biophysical techniques
• Cyclodextrins
• Nanosystems
• Pharmaceutical drug target

• Department of Chemistry, National and Kapodistrian University of Athens, Zografou, Greece

  Thomas Mavromoustakos

• Department of Chemistry Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina, Greece

  Andreas G. Tzakos

• Computational Biology and Molecular Simulations Laboratory Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey

  Serdar Durdagi

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