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  • © 2021

Computational Methods in Synthetic Biology

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2189)

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Table of contents (17 protocols)

  1. Front Matter

    Pages i-x
  2. Using a Design of Experiments Approach to Inform the Design of Hybrid Synthetic Yeast Promoters

    • James Gilman, Valentin Zulkower, Filippo Menolascina
    Pages 1-17
  3. Computational Design of Multiplex Oligonucleotide-Based Assays

    • Michaela Hendling, Ivan BariÅ¡ić
    Pages 19-30
  4. Modular Modeling of Genetic Circuits in SBML Level 3

    • Mario Andrea Marchisio
    Pages 45-63
  5. iGUIDE Method for CRISPR Off-Target Detection

    • Christopher L. Nobles
    Pages 71-80
  6. Synthetic Gene Circuit Analysis and Optimization

    • Irene Otero-Muras, Julio R. Banga
    Pages 89-103
  7. Construction of Protein Expression Network

    • Nor Afiqah-Aleng, Zeti-Azura Mohamed-Hussein
    Pages 119-132
  8. Systems-Theoretic Approaches to Design Biological Networks with Desired Functionalities

    • Priyan Bhattacharya, Karthik Raman, Arun K. Tangirala
    Pages 133-155
  9. A Deterministic Compartmental Modeling Framework for Disease Transmission

    • King James B. Villasin, Eva M. Rodriguez, Angelyn R. Lao
    Pages 157-167
  10. Computer Aided Assembly and Verification of Synthetic Chromosomes

    • Giovanni Stracquadanio, Valentin Zulkower
    Pages 169-181
  11. Minimal Genome Design Algorithms Using Whole-Cell Models

    • Joshua Rees-Garbutt, Oliver Chalkley, Claire Grierson, Lucia Marucci
    Pages 183-198
  12. Tn-Core: Functionally Interpreting Transposon-Sequencing Data with Metabolic Network Analysis

    • George C. diCenzo, Marco Galardini, Marco Fondi
    Pages 199-215
  13. A Systems Bioinformatics Approach to Interconnect Biological Pathways

    • George Minadakis, George M. Spyrou
    Pages 231-249
  14. Back Matter

    Pages 251-255

About this book

This second edition book provides complete coverage of the computational approaches currently used in Synthetic Biology.  New chapters detail computational methods and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Computational Methods in Synthetic Biology, Second Edition aims to feature a broad overview of the research areas that can be met in the area of in silico Synthetic Biology.


Editors and Affiliations

  • School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China

    Mario Andrea Marchisio

Bibliographic Information

  • Book Title: Computational Methods in Synthetic Biology

  • Editors: Mario Andrea Marchisio

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-0822-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-0821-0Published: 13 November 2020

  • Softcover ISBN: 978-1-0716-0824-1Published: 13 November 2021

  • eBook ISBN: 978-1-0716-0822-7Published: 12 November 2020

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: X, 255

  • Number of Illustrations: 39 b/w illustrations, 58 illustrations in colour

  • Topics: Bioinformatics, Biotechnology, Biological Techniques

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access