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Immuno-Oncology

Cellular and Translational Approaches

  • Book
  • © 2020

Overview

Editors:
  1. Seng-Lai Tan

    1. Elstar Therapeutics, Cambridge, USA

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  • Features practical approaches to immunotherapeutic cancer research
  • Contains key implementation advice from the experts
  • Provides guidance for developing next generation translational assays

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. An In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies

    • Min Dai, Ingegerd Hellstrom, Karl Erik Hellstrom
    Pages 1-12

  3. High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry

    • Leo Li-Ying Chan
    Pages 13-34

  4. In Vitro Functional Assay Using Real-Time Cell Analysis for Assessing Cancer Immunotherapeutic Agents

    • Biao Xi, Peifang Ye, Vita Golubovskaya, Yama Abassi
    Pages 35-50

  5. Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays

    • Tomasz Dobrzycki, Andreea Ciuntu, Andrea Stacey, Joseph D. Dukes, Andrew D. Whale
    Pages 51-72

  6. Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates

    • Eden Kleiman, Wushouer Ouerkaxi, Marc Delcommenne, Geoffrey W. Stone, Paolo Serafini, Mayra Cruz Tleugabulova et al.
    Pages 73-88

  7. A Human In Vitro T Cell Exhaustion Model for Assessing Immuno-Oncology Therapies

    • Lynne S. Dunsford, Rosie H. Thoirs, Emma Rathbone, Agapitos Patakas
    Pages 89-101

  8. Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay

    • Brad Larson, Lubna Hussain, Jenny Schroeder
    Pages 103-115

  9. 3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment

    • Sofia P. Rebelo, Catarina Pinto, Nuno Lopes, Tatiana R. Martins, Paula Marques Alves, Catarina Brito
    Pages 117-130

  10. Considerations in Developing Reporter Gene Bioassays for Biologics

    • Jamison Grailer, Richard A. Moravec, Zhijie Jey Cheng, Manuela Grassi, Vanessa Ott, Frank Fan et al.
    Pages 131-156Open Access

  11. Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies

    • Thomas Jacob, Pavani Malla, Tania Vu
    Pages 157-165

  12. Precision Medicine: The Function of Receptor Occupancy in Drug Development

    • Leanne Flye-Blakemore, Christèle Gonneau, Nithianandan Selliah, Ajay Grover, Sriram Ramanan, Alan Lackey et al.
    Pages 167-197

  13. In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics

    • Jinze Li, Mayur S. Mitra, Gautham K. Rao
    Pages 199-238

  14. The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era

    • Leonardo Mirandola, Franco Marincola, Gianluca Rotino, Jose A. Figueroa, Fabio Grizzi, Robert Bresalier et al.
    Pages 239-253

  15. Correction to: Considerations in Developing Reporter Gene Bioassays for Biologics

    • Jamison Grailer, Richard A. Moravec, Zhijie Jey Cheng, Manuela Grassi, Vanessa Ott, Frank Fan et al.
    Pages C1-C1

  16. Back Matter

    Pages 255-262
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Keywords

About this book

This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab. 

Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics.

Editors and Affiliations

  • Elstar Therapeutics, Cambridge, USA

    Seng-Lai Tan

Bibliographic Information

  • Book Title: Immuno-Oncology

  • Book Subtitle: Cellular and Translational Approaches

  • Editors: Seng-Lai Tan

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-0716-0171-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2020

  • Hardcover ISBN: 978-1-0716-0170-9Published: 07 January 2020

  • Softcover ISBN: 978-1-0716-0173-0Published: 24 March 2021

  • eBook ISBN: 978-1-0716-0171-6Published: 06 January 2020

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: X, 262

  • Number of Illustrations: 8 b/w illustrations, 83 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Cancer Research, Immunology

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