Novel therapeutic approaches for gastrointestinal malignancies

1. Front Matter

   Pages i-xii

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2. Targeting Pathways in GI Malignancies

   • Neha Merchant, Ganji Purnachandra Nagaraju

   Pages 1-14

3. Immunotherapy in Gastrointestinal Malignancies

   • Ritu Sarin, Sujatha Peela

   Pages 15-29

4. Adiponectin in Gastrointestinal Malignancies

   • Batoul Farran, Iffat Zahin Atiquah, Dongkyoo Park

   Pages 31-42

5. Small Molecule-Targeted Therapies for GI Cancers: Success and Failures

   • Binayak Kumar, Deepu Sharma, Jyotsna Gorantala, Sri Krishna Jayadev Magani

   Pages 43-57

6. Epigenetic Biomarkers for the Detection of Gastrointestinal Cancers

   • Syamala Soumyakrishnan, Rashmi Nagesh, Sujatha Peela, Meenakshisundaram Sreepriya

   Pages 59-82

7. CD151: A Lateral Organizer and Modulator of Tumor Microenvironment in Gastrointestinal Cancers

   • Rama Rao Malla

   Pages 83-99

8. Identification of Potential Key Genes Involved in Progression of Gastric Cancer Using Bioinformatics Analysis

   • Vigneshwar Suriya Prakash Sinnarasan, Dahrii Paul, Leimarembi Devi Naorem, Mathavan Muthaiyan, Dinakara Rao Ampasala, Amouda Venkatesan

   Pages 101-114

9. Recent Development in the Biomarkers for the Gastric Cancer

   • Dhananjay Shukla, Saurabh Saxena, Pranav Kumar Prabhakar

   Pages 115-138

10. Gastric Cancer and Its Remedy

    • Abdul Alim, Rokshana Sharmin, Dongkyoo Park, Abu Syed Md Anisuzzaman

    Pages 139-158

11. An Intergenic Variant rs4779584 Between SCG5 and GREM1 Contributes to the Increased Risk of Colorectal Cancer: A Meta-Analysis

    • Samrat Rakshit, L. V. K. S. Bhaskar

    Pages 159-169

12. Phytochemicals Plus Nanomaterial’s on Colorectal Cancer

    • Prameswari Kasa, Gayathri Chalikonda, Ganji Seeta Rama Raju

    Pages 171-191

13. Role of Selected Transcription Factors in Pancreatic and Colorectal Cancer Growth and Metastasis

    • Sujatha Peela, Dariya Begum, Ganji Purnachandra Nagaraju

    Pages 193-207

14. Pancreatic Ductal Adenocarcinoma and Type 2 Diabetes Mellitus: Distant Relatives or the Close Ones?

    • Kumari Subham, Sonali Mohanty, Sonali Jena, Monalisha Ojha, Suman Jha

    Pages 209-237

15. Tumor Biomarkers and Diagnosis of Pancreatic Adenocarcinoma

    • Ishtiaq Hussain, Mamoon Ur Rashid, Jamaluddin Saeed, Zarghoona Wajid, Deepika Sarvepalli, Effa Zahid et al.

    Pages 239-252

16. The Role of HIF-1α in Hepatocellular Carcinoma

    • Saimila Momin, Ganji Purnachandra Nagaraju

    Pages 253-259

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents.

Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

• GI cancer
• Targeted therapies
• Theranostics
• Biomarkers
• Nanotechnology
• Diagnostic Radiology
• gene expression

• Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, USA

  Ganji Purnachandra Nagaraju

• Department of Biotechnology, Dr. B.R. Ambedkar University, Srikakulam, India

  Sujatha Peela

Dr. Nagaraju GP is a faculty member in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Nagaraju obtained his PhD, in Biotechnology, from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. Dr. Nagaraju received his DSc from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju’s research focuses on translational projects related to gastrointestinal malignancies. He has published over 90 research papers in highly reputed International journals and has presented more than 50 abstracts at various national and international conferences. Dr, Nagaraju is author and editor of several published books. He serves as editorial board member of several internationally recognized academic journals. Dr. Nagaraju is an associate member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute. Dr. Nagaraju has received several international awards including FAACC. He also holds memberships with many international and national professional agencies.

Dr. Sujatha Peela is a full-time Professor in the Department of Biotechnology, Dr.B.R.Ambedkar University, Srikakulam, Andhra Pradesh, INDIA. Dr. Peela received her Doctorate in Biotechnology from Andhra University, Visakhapatnam, INDIA. Furthermore, she pursued her postdoctoral fellowship from the University of Chicago, USA in the Department of Medicine. She has published 33 research papers in various highly reputed International journals and attended 84 national and international conferences. Dr. Peela has published 4 books at international level. She received many prestigious awards from many government agencies & NGOs. Currently, she is playing critical roles in the administration of the state & central including, Principal, for College of Science, Dean for Research Development & Foreign Relations, Faculty Chairperson, in Dr.B.R. Ambedkar University. She organized 16 national and internationalconferences at various platforms in the Biotechnology field. She has one patent TEMP/E-1/44893/2018-DEL in India. She has membership with many international and national professional agencies.

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