Plant-derived Bioactives

1. Front Matter

   Pages i-xix

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2. Orientin: A C-Glycosyl Flavonoid that Mitigates Colorectal Cancer

   • Manju Vaiyapuri, Karthi Natesan, Bala Murali Krishna Vasamsetti, Manjulatha Mekapogu, Mallappa Kumara Swamy, Kalaiyarasu Thangaraj

   Pages 1-19

3. Plant Flavonoids Against Colorectal Cancer and Mechanisms of Action

   • Srivalli Thimmarayan, Mahalakshmi Manickam, Manjulatha Mekapogu, Bala Murali Krishna Vasamsetti, Mallappa Kumara Swamy, Karthi Natesan et al.

   Pages 21-34

4. Plant Neoflavonoids: Chemical Structures and Biological Functions

   • Padam Kumar, Tanveer Ahamad, Devendra Pratap Mishra, Mohammad Faheem Khan

   Pages 35-57

5. Polyphenols’ Role in Autoimmune and Chronic Inflammatory Diseases and the Advent of Computer-Driven Plant Therapies

   • Glaucia C. Pereira

   Pages 59-84

6. Plant Alkaloids: Structures and Bioactive Properties

   • Erick Paul Gutiérrez-Grijalva, Leticia Xochitl López-Martínez, Laura Aracely Contreras-Angulo, Cristina Alicia Elizalde-Romero, José Basilio Heredia

   Pages 85-117

7. Pelargonidin, a Dietary Anthocyanidin in the Prevention of Colorectal Cancer and Its Chemoprotective Mechanisms

   • Manju Vaiyapuri, Srivalli Thimmarayan, Madhusmitha Dhupal, Harikrishna Reddy Rallabandi, Manjulatha Mekapogu, Bala Murali Krishna Vasamsetti et al.

   Pages 119-135

8. Targeting the Key Signaling Pathways in Breast Cancer Treatment Using Natural Agents

   • Suresh Kumar Anandasadagopan, Prathibha Sivaprakasam, Srinivetha Pathmanapan, Ashok Kumar Pandurangan, Tamilselvi Alagumuthu

   Pages 137-183

9. Chromenes: Phytomolecules with Immense Therapeutic Potential

   • Mohd Kamil Hussain, Mohammad Faheem Khan, Shahnaaz Khatoon, Abdullah G. Al-Sehemi, Mohammad Saquib

   Pages 185-204

10. Coumarins: An Important Phytochemical with Therapeutic Potential

    • Dilipkumar Pal, Supriyo Saha

    Pages 205-222

11. Pomegranate Peel and Its Anticancer Activity: A Mechanism-Based Review

    • Talambedu Usha, Sushil Kumar Middha, Kora Rudraiah Sidhalinghamurthy

    Pages 223-250

12. Lycopene: Chemistry, Biosynthesis, Health Benefits and Nutraceutical Applications

    • Shubhi Singh, Smriti Gaur

    Pages 251-263

13. Dietary Agents in the Prevention of Cataractogenesis: Results from Preclinical Observations

    • May D’souza, Sripathi Kamath, Michael L. J. Pais, Mohammed Adnan, Nimith D’souza, Mallappa Kumara Swamy et al.

    Pages 265-279

14. Bioactive Xanthones from Garcinia mangostana

    • Yong Sze Ong, Vikneswaran Murugaiyah, Bey Hing Goh, Kooi Yeong Khaw

    Pages 281-300

15. Capsaicin and Its Potential Anticancer Mechanisms of Action

    • Ravindran Jaganathan, Boregowda Purushotham, Narayanaswamy Radhakrishnan, Mallappa Kumara Swamy

    Pages 301-321

16. Biosynthesis, Genetic Regulation and Therapeutic Potential of Capsaicinoids

    • Ajay Kumar, Ginkuntla Saikiran, Thattantavide Anju, Vengaroth Kundancherry Anusree, Korambeth Jasna, Yash Pal Sharma et al.

    Pages 323-350

17. Phytochemicals in the Prevention and Cure of Cancers

    • Nilesh Shirish Wagh, Sandeep Ramchandra Pai, Varsha Vasantrao Sonkamble

    Pages 351-373

18. Anticancer and Chemopreventive Phytochemicals from Cruciferous Plants

    • Nida Idrees, Mohammad Saquib, Sarfuddin Azmi, Irfan Ahmad, Mohd Kamil Hussain

    Pages 375-385

19. Pharmacological Properties of Essential Oil Constituents and their Mechanisms of Action

    • Bibi Sharmeen Jugreet, Mohamad Fawzi Mahomoodally

    Pages 387-415

20. Neuroprotective Compounds from Plant Sources and their Modes of Action: An Update

    • Sandra Gonçalves, Inês Mansinhos, Anabela Romano

    Pages 417-440

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. 

This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, “Plant-derived Bioactives: Chemistry and Mode of Action” discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives.

Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of new drugs.

• Bioactivities
• Herbal medicine
• Medicinal plants
• Natural products
• Therapeutics

• Department of Biotechnology, East West First Grade College, Bengaluru, India

  Mallappa Kumara Swamy

Dr. Mallappa Kumara Swamy is a Professor at the Department of Biotechnology at East West First Grade College (Affiliated to Bangalore University), Bengaluru, India. He pursued his postdoctoral research at the Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia (UPM), Serdang, Malaysia from 2014 to 2018. Before that, he worked as an Associate Professor and Head of the Department of Biotechnology at Padmashree Institute of Management and Sciences, Bangalore University, Bengaluru, India. He obtained his PhD (Biotechnology) from Acharya Nagarjuna University, Guntur, India in 2013. He has more than 16 years of teaching and research experience in the fields of plant biotechnology, secondary metabolites production, phytochemistry and bioactive studies, and he has published more than 100 research papers in peer-reviewed journals and 25 book chapters. He has edited 10 books with Springer Nature Singapore Pte Ltd., CRC Press (Taylor & Francis Group), USA, and Studium Press, India. He is also an editorial board member and reviewer for various high- impact international journals. He currently works in the area of natural product research, plant cell and tissue culture technology for bioactive compounds production and evaluation of their bioactivities. His research also focuses on nanobiotechnology for medical applications.

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