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Progranulin and Central Nervous System Disorders

Editors: Hara, H., Hosokawa, M., Nakamura, S., Shimohata, T., Nishihara, M. (Eds.)

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  • Reviews the effects and mechanisms of action of progranulin
  • Explores the value of progranulin as a therapeutic target
  • Discusses emerging treatment approaches for CNS disorders
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書籍の購入

イーブック ¥12,354
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-6186-9
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
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ハードカバー ¥21,059
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-6185-2
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
この書籍について

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.


著者について

Hideaki Hara, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan

Masato Hosokawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan

Shinsuke Nakamura, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan

Takayoshi Shimohata, Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Japan  

Masugi Nishihara, Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan


Table of contents (11 chapters)

Table of contents (11 chapters)

書籍の購入

イーブック ¥12,354
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-6186-9
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー ¥21,059
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-6185-2
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Progranulin and Central Nervous System Disorders
Editors
  • Hideaki Hara
  • Masato Hosokawa
  • Shinsuke Nakamura
  • Takayoshi Shimohata
  • Masugi Nishihara
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
イーブック ISBN
978-981-13-6186-9
DOI
10.1007/978-981-13-6186-9
ハードカバー ISBN
978-981-13-6185-2
Edition Number
1
Number of Pages
VII, 183
Number of Illustrations
24 b/w illustrations, 13 illustrations in colour
Topics