Targeting Protein-Protein Interactions by Small Molecules

Editors: Sheng, Chunquan, Georg, Gunda I. (Eds.)

  • Provides a comprehensive description of state-of-the-art strategies for the discovery of small molecule inhibitors of protein-protein interactions
  • Highlights successful examples and the clinical development of small molecule inhibitors of protein-protein interactions
  • Describes the recent advances in small molecule inhibitors acting on new targets
  • Presents an in-depth discussion on the merits and limitations of various technologies and offers new perspectives to guide future research
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イーブック ¥15,070
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-0773-7
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
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ハードカバー ¥18,838
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-0772-0
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
この書籍について

This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities. 


著者について

Chunquan Sheng is currently a Professor, Vice Dean of the School of Pharmacy and the Director of the Department of Medicinal Chemistry at Second Military Medical University (SMMU), P. R. China. He received his PhD degree in Medicinal Chemistry (2005) from SMMU and then worked at the Department of Medicinal Chemistry, School of Pharmacy at SMMU. His research interests include structure-based design and synthesis of drug-like molecules with an emphasis on small molecule inhibitors of protein–protein interactions and multi-targeting drugs. He has published more than 100 research articles and invited reviews in prestigious journals in the field of medicinal chemistry and holds more than 10 patents. He was supported by several programs, including the National Outstanding Young Scholarship from the National Natural Science Foundation of China (NSFC). 

Gunda I. Georg is Professor and Head of the Department of Medicinal Chemistry and the founding Director of the Institute for Therapeutics Discovery and Development (ITDD) at the University of Minnesota College of Pharmacy. She holds the Robert Vince Endowed Chair and the McKnight Presidential Chair in Medicinal Chemistry. She is the Co-Editor-in-Chief of the Journal of Medicinal Chemistry, the most cited journal in the field.  Dr. Georg received a BS in Pharmacy (1975) and a PhD degree in Medicinal Chemistry (1980) from the Philipps University of Marburg, Germany.  She was a postdoctoral fellow at the Department of Chemistry at the University of Ottawa in Canada.  After 22 years as a faculty member at the University of Kansas, she joined the University of Minnesota in 2007.  Her research focuses on the design, synthesis, and evaluation of biologically active agents.

Table of contents (12 chapters)

  • Overview of Protein-Protein Interactions and Small-Molecule Inhibitors Under Clinical Development

    Dong, Guoqiang (et al.)

    Pages 3-28

    Preview Buy Chapter ¥3,412
  • High-Throughput Screening in the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions

    Zhuang, Chunlin (et al.)

    Pages 29-51

    Preview Buy Chapter ¥3,412
  • Hot Spot-Based Design of Small-Molecule Inhibitors for Protein-Protein Interactions

    Ji, Haitao

    Pages 53-71

  • Computational Methods Applicable to the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions

    Han, Li (et al.)

    Pages 73-94

  • Experimental Methods Used for Identifying Small-Molecule Inhibitors of Protein-Protein Interaction

    Zhou, Mi (et al.)

    Pages 95-133

書籍の購入

イーブック ¥15,070
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-0773-7
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー ¥18,838
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-981-13-0772-0
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Targeting Protein-Protein Interactions by Small Molecules
Editors
  • Chunquan Sheng
  • Gunda I. Georg
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
イーブック ISBN
978-981-13-0773-7
DOI
10.1007/978-981-13-0773-7
ハードカバー ISBN
978-981-13-0772-0
Edition Number
1
Number of Pages
XI, 329
Number of Illustrations and Tables
32 b/w illustrations, 100 illustrations in colour
Topics