Springer Theses

Total Synthesis of Natural Products with Antimicrobial Activity

Authors: Giltrap, Andrew

  • Focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery 
  • Describes the total synthesis of two antimicrobial non-ribosomal peptides (NRPs) classes: teixobactin and skyllamycins 
  • Demonstrates how synthetic NRPs’ natural products can be used to inhibit the growth of biofilms and combat bacterial pathogens
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書籍の購入

イーブック 107,09 €
価格の適用国: Japan (小計)
  • ISBN 978-981-10-8806-3
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
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  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー 129,99 €
価格の適用国: Japan (小計)
  • ISBN 978-981-10-8805-6
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
この書籍について

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

著者について

Andrew M. Giltrap was raised in Sydney, Australia and carried out his Bachelor of Science majoring in chemistry at the University of Sydney. During this time, Andrew undertook his final year undergraduate research project under the supervision of Professor Richard J. Payne, receiving the University Medal for undergraduate excellence. Andrew continued in the laboratory of Professor Payne, commencing his PhD studies in 2013 funded by an Australian Postgraduate Award, the Sydney University Vice-Chancellor’s Research Scholarship and the John A. Lamberton Scholarship. During his PhD, Andrew’s research focused on the total synthesis of antimicrobial peptide natural products, notably completing the first total syntheses of teixobactin and skyllamycins A-C. He is currently a postdoctoral research associate at the University of Sydney.

Table of contents (5 chapters)

  • Introduction

    Giltrap, Andrew

    Pages 1-31

    Preview Buy Chapter 26,95 €
  • Total Synthesis of Teixobactin

    Giltrap, Andrew

    Pages 33-69

  • Synthesis of Deshydroxy Skyllamycins A–C

    Giltrap, Andrew

    Pages 71-117

    Preview Buy Chapter 26,95 €
  • Total Synthesis of Skyllamycins A–C

    Giltrap, Andrew

    Pages 119-150

  • Experimental

    Giltrap, Andrew

    Pages 151-223

書籍の購入

イーブック 107,09 €
価格の適用国: Japan (小計)
  • ISBN 978-981-10-8806-3
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: EPUB, PDF
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー 129,99 €
価格の適用国: Japan (小計)
  • ISBN 978-981-10-8805-6
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Total Synthesis of Natural Products with Antimicrobial Activity
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
イーブック ISBN
978-981-10-8806-3
DOI
10.1007/978-981-10-8806-3
ハードカバー ISBN
978-981-10-8805-6
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXIV, 268
Number of Illustrations and Tables
85 b/w illustrations, 59 illustrations in colour
Topics