Cancer Drug Delivery Systems Based on the Tumor Microenvironment

Editors: Matsumura, Yasuhiro, Tarin, David (Eds.)

Free Preview
  • Introduces drug design based on cancer pathophysiology
  • Describes the benefits of a drug delivery system that integrates nanotechnology, biotechnology, and nano biotechnology 
  • Explains the new cancer drug step by step
おすすめポイントをすべて見る

書籍の購入

イーブック ¥16,015
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-4-431-56880-3
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
ハードカバー ¥20,019
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
この書籍について

This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.

著者について

Yasuhiro Matsumura, MD, PhD, Director, Division of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Japan

David Tarin, MD, PhD, FRCPath, Professor of Pathology, UC San Diego Moores Cancer Center, University of California, USA


Table of contents (14 chapters)

Table of contents (14 chapters)

書籍の購入

イーブック ¥16,015
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
  • ISBN 978-4-431-56880-3
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
ハードカバー ¥20,019
価格の適用国: Japan (日本円価格は個人のお客様のみ有効) (小計)
Loading...

この書籍のサービス情報

あなたへのおすすめ

Loading...

書誌情報

Bibliographic Information
Book Title
Cancer Drug Delivery Systems Based on the Tumor Microenvironment
Editors
  • Yasuhiro Matsumura
  • David Tarin
Copyright
2019
Publisher
Springer Japan
Copyright Holder
Springer Japan KK, part of Springer Nature
イーブック ISBN
978-4-431-56880-3
DOI
10.1007/978-4-431-56880-3
ハードカバー ISBN
978-4-431-56878-0
Edition Number
1
Number of Pages
XI, 325
Number of Illustrations
45 b/w illustrations, 73 illustrations in colour
Topics