Overview
- Applies computational methods to simulate the electrostatic interaction of protein molecules to form complexes and domains
- Predicts amino acid sequences with specific physical properties
- Helps to improve the efficiency of experiments
Part of the book series: Biological and Medical Physics, Biomedical Engineering (BIOMEDICAL)
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Table of contents (8 chapters)
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Front Matter
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Back Matter
Keywords
- Protein Domain Binding
- Effect of Phosphorylation on binding of proteins
- Calculation of Reactivity of Proteins
- Temperature Dependence Protein Complexes
- Salt Dependence Protein Complexes
- Amino Acids and Proteins
- Histone Dimer Formation
- Binding of Monomeric Proteins
- Phosphorylation Effect
- Simulation of Protein Complex Formation
- Protein Structure
About this book
This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins. The models also take the phosphorylation of amino acid residues into account.
At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.
Reviews
Authors and Affiliations
About the authors
Kirill Kulikov has been a full professor since 2014 at Peter the Great St. Petersburg Polytechnical University, Institute of Applied Mathematics and Mechanics, Department of Higher Mathematics. He received his Ph.D. in Physics and Mathematics with «Mathematical Modeling of the Optical Properties of Multilayer Biological Systems and Structures in their Heterogeneous Conjugation» (2004). He has habilitation at the State Polytechnical University (Great St. Petersburg Polytechnical University) of St. Petersburg, Russia (Doctor Science in Physics and Mathematics). His Doctor of Science thesis title was «Analytical models of interaction of laser radiation with complex heterogeneous biological tissues» (2014). His research interests are theory diffraction theory, electrodynamics, physics of lasers, tissue optical methods of mathematical modeling in biological tissue optics and numerical method, biophysics.
Bibliographic Information
Book Title: Mathematical Modeling of Protein Complexes
Authors: Tatiana Koshlan, Kirill Kulikov
Series Title: Biological and Medical Physics, Biomedical Engineering
DOI: https://doi.org/10.1007/978-3-319-98304-2
Publisher: Springer Cham
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer Nature Switzerland AG 2018
Hardcover ISBN: 978-3-319-98303-5Published: 06 September 2018
Softcover ISBN: 978-3-030-07481-4Published: 28 December 2018
eBook ISBN: 978-3-319-98304-2Published: 24 August 2018
Series ISSN: 1618-7210
Series E-ISSN: 2197-5647
Edition Number: 1
Number of Pages: XIV, 367
Number of Illustrations: 17 b/w illustrations, 48 illustrations in colour
Topics: Biological and Medical Physics, Biophysics, Protein Structure, Numerical and Computational Physics, Simulation, Mathematical and Computational Biology, Biomedical Engineering and Bioengineering