Topics in Heterocyclic Chemistry

Free-Radical Synthesis and Functionalization of Heterocycles

Editors: Landais, Yannick (Ed.)

  • Provides readers with an overview of free-radical chemistry as an environmentally benign synthetic strategy to access heterocycles
  • Emphasizes the high bond forming efficiency of using radical cascade and electron-transfer processes
  • Highlights the latest developments in use of light and metal-catalysis to trigger single electron transfer (SET) processes
  • Covers many different examples including detailed mechanistic insights
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イーブック 190,39 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-89521-5
  • ウォーターマーク付、 DRMフリー
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ハードカバー 229,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-89520-8
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この書籍について

This volume describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural heterocycles. As organic chemists strive towards sustainability, radical chemistry has recently seen major advances and efforts in this direction, including C-H activation of arenes and unactivated alkyl groups. Photochemical activation, for a long time the preferred mode of activation in radical chemistry has also seen an unexpected revival with the advent of visible light metal- and organocatalyzed photoredox processes. A survey of these emerging areas is provided along with the concepts at the origin of these developments.

The venerable Minisci reaction allows for direct access to functionalized heterocycles. This process has lately seen an interesting renaissance and is discussed in this volume. Addition of heteroatom-centered radicals onto unsaturated systems constitutes another powerful method to construct heterocycles. Examples of such a strategy are proposed along with the formation of various heterocycles relying on homolytic substitution at sulfur, phosphorus and selenium. Additionally free-radical functionalization of reactive functional groups including isonitriles, isothiocyanates and related unsaturated systems which offer a straightforward route towards useful aromatic and non-aromatic heterocycles are discussed. Finally, as metals are able to trigger single electron transfer both in reductive and oxidative modes this provides another possibility for the synthesis of heterocycles. Significant research efforts have focused on the use of samarium, copper and other metals to access a broad variety of heterocycles in a single pot process, starting from readily available raw material. Examples and mechanistic insights are discussed by experts in this area.

著者について

Yannick Landais was born in Angers (France) in 1962. He received his PhD in chemistry from the University of Orsay (Paris XI) under the supervision of Dr. Jean-Pierre Robin. After carrying out post-doctoral studies with Prof. Ian Fleming at Cambridge University (1988-1990), he took a position of Maitre-Assistant at the University of Lausanne (1990-1997). He was then appointed at the University Bordeaux-I where he is currently Professor of organic chemistry. His research interests are in synthetic organic chemistry, asymmetric synthesis, radical chemistry, with a special emphasis on organosilicon chemistry and its applications in total synthesis of natural products. In 1997, he was awarded the Werner prize by the New Swiss Chemical Society. Between 2000 and 2005, he was a member of the Institut Universitaire de France. In 2014, he was elected as a senior Distinguished Member of the Société Chimique de France (SCF) and was awarded the SCF's Organic Chemistry Division prize the same year. He is currently President of the French-Japanese Chemical Society and is a member of the International Advisory Board of the European Journal of Organic Chemistry.

Table of contents (8 chapters)

  • Photocatalyzed Formation of Heterocycles

    Crespi, Stefano (et al.)

    Pages 1-69

  • C–H Activation via Radical Processes Using Photo-Excited Ketones

    Kamijo, Shin

    Pages 71-92

  • Free Radicals in Heterocycle Functionalization

    Joseph, Jomy (et al.)

    Pages 93-149

    Preview Buy Chapter 26,95 €
  • Heteroatom-Centred Radicals for the Synthesis of Heterocyclic Compounds

    Dénès, Fabrice

    Pages 151-230

  • Metal-Mediated Oxidative Radical Processes for the Synthesis of Heterocycles

    Tejo, Ciputra (et al.)

    Pages 231-252

書籍の購入

イーブック 190,39 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-89521-5
  • ウォーターマーク付、 DRMフリー
  • ファイル形式: PDF, EPUB
  • どの電子書籍リーダーからでもすぐにお読みいただけます。
  • ご購入後、すぐにダウンロードしていただけます。
ハードカバー 229,99 €
価格の適用国: Japan (小計)
  • ISBN 978-3-319-89520-8
  • 個人のお客様には、世界中どこでも配送料無料でお届けします。
  • Usually dispatched within 3 to 5 business days.
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書誌情報

Bibliographic Information
Book Title
Free-Radical Synthesis and Functionalization of Heterocycles
Editors
  • Yannick Landais
Series Title
Topics in Heterocyclic Chemistry
Series Volume
54
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
イーブック ISBN
978-3-319-89521-5
DOI
10.1007/978-3-319-89521-5
ハードカバー ISBN
978-3-319-89520-8
Series ISSN
1861-9282
Edition Number
1
Number of Pages
VII, 352
Number of Illustrations and Tables
436 b/w illustrations, 18 illustrations in colour
Topics